Ph.D. in Biomedical Science: Thematic Research Areas
Development and Differentiation
Hector Leo Aguila, Assistant Professor of
Immunology, Ph.D., Albert
Einstein College of Medicine. Hematopoiesis and bone marrow
microenvironment; lymphoid cell development; stem cell biology.
Rashmi Bansal,
Associate Professor of Neuroscience; Ph.D., Central Drug Res. Institute,
1976. The developmental, cellular and molecular biology of
oligodendrocytes (OLs).
Elisa Barbarese,
Professor of Neuroscience, Ph.D., McGill University.
Developmental neurobiology, myelination, and multiple sclerosis.
Choukri Ben
Mamoun, Ph.D., Associate Professor of Genetics and Developmental
Biology. Cell signaling and transport of nutrients in the human malaria
parasite plasmodium falciparum.
John H. Carson, Professor of Molecular,
Microbial and Structural Biology, B.A., Reed College, Ph.D.,
Massachusetts Institute of Technology. RNA transport in cells of the
nervous system.
Stephen Clark, Ph.D., Associate Professor of Genetics and
Developmental Biology. Characterization of mutations affecting
connective tissues; molecular genetic mapping; generation and analysis
of transgenic mice.
Stephen J. Crocker, Assistant
Professor of Neuroscience, Ph.D., University of Ottowa.
Stem cells; glia; metalloproteinases; cytokines; development; pathology;
tissue culture.
Caroline N.
Dealy, Ph.D., Associate Professor of Oral Rehabilitation,
Biomaterials and Skeletal Development, Center for Regenerative Medicine
and Skeletal Development.
The molecular regulation of limb
development in the vertebrate embryo, from early stages where the limb
is initially formed, to limb patterning and outgrowth, to skeletogenesis.
Paul Epstein,
Ph.D., Associate Professor of Cell Biology. Receptor signal
transduction, second messengers, and protein phosphorylation in control
of cell growth and regulation; purification and regulation of cyclic
nucleotide phosphodiesterases; role of calmodulin in mediating Ca2+-dependent
cell processes.
Guo-Hua Fong, Assistant Professor of Cell Biology, Ph.D., University
of Illinois. Developmental biology of the vascular system, VEGF-A
receptor signal transduction, embryonic stem cells and gene knock-out in
mice.
Henry M. Furneaux, Associate Professor of Molecular, Microbial and
Structural Biology; Ph.D., University of Aberdeen, Scotland. The
regulation of gene expression at the posttranscriptional level.
Brenton R. Graveley, Associate Professor of Genetics and
Developmental Biology. Ph.D. University of Vermont, 1996. Regulation of
alternative pre-mRNA splicing.
Gloria
Gronowicz, Professor and Director of Orthopaedic Research,
Department of Orthopaedics, Ph.D., Columbia University. Effects of
hormones and growth factors on the production of extracellular matrix (ECM)
proteins, on the regulation of integrins (receptors for ECM proteins)
and on apoptosis in bone; response of bone cells to implant
biomaterials.
Arthur R. Hand, Professor of Orthodontics and Maxillofacial Surgery,
Pediatric Dentistry and Advanced Education in General Dentistry,
Division of Pediatric Dentistry, D.D.S., University
of California, Los Angeles. Study of gene expression in rodent salivary
glands during normal growth and development and in various experimental
conditions employing morphological, immunological and biochemical
methodology.
Marc Hansen, Professor of Medicine, M.S., University of Wisconsin
1982, Ph.D. University of Cincinnati College of Medicine 1986. Molecular
genetics of osteosarcoma and related bone diseases.
Timothy Hla,
Professor of Cell Biology; Ph.D., George Washington University, 1988.
Molecular mechanisms of angiogenesis, G-protein-coupled receptor
signaling, Cyclooxygenase (Cox-2) and cancer, lipid mediators.
Marja Hurley, Professor of Medicine, M.D., University of Connecticut
School of Medicine. Molecular mechanisms by which members of the fibroblast growth factor (FGFs)
and fibroblast growth factor receptor (FGFR) families, (produced by
osteoblasts, osteoclasts and stromal cells) regulate bone development,
remodeling and disorders of bone. Fgf2 knockout and Fgf2 transgenic mice
are utilized in loss and gain of function experiments to elucidate the
role of FGF-2 in disorders of bone including osteoporosis.
Laurinda A. Jaffe, Professor of Cell Biology; Ph.D., UCLA, 1977. The
cell biology of fertilization, and the regulation of meiosis in oocytes.
Robert A. Kosher, Ph.D., Professor Department of Biostructure and
Function. Limb development; roles and relationships among regulatory
genes particularly homeobox-containing genes, secreted signaling
molecules, and the extracellular matrix in the regulation of limb
formation, outgrowth, patterning, cartilage differentiation,
osteogenesis, and joint formation.
Barbara Kream,
Ph.D., Professor of Medicine and Genetics and Developmental Biology.
Hormonal regulation of bone remodeling.
Marc Lalande,
Ph.D., Professor and Head of Genetics and Developmental Biology. Epigenetics
including the control of gene expression in embryonic carcinoma stem
cells and genomic imprinting and its association with neurogenetics
disorders.
Leo
Lefrancois, Professor of Immunology, B.S., Colorado State
University; Ph.D., Wake Forest University. T-cell activation and
migration, T-cell memory; immune response to infection; tolerance;
vaccines.
James Li, Ph.D.,
Assistant Professor. Development
of the central nervous system (CNS), with an emphasis on the mammalian
cerebellum.
Xuejun (June) Li, Assistant
Professor of Neuroscience, Ph.D., Fudan University.
Stem cells; neural development and degeneration.
Alexander Lichtler, Ph.D., Associate Professor of Genetics and
Developmental Biology. Regulation of collagen gene transcription;
retrovirus vectors; role of homeobox genes in limb development.
Mina Mina,
Professor of Orthodontics and Maxillofacial Surgery, Pediatric Dentistry
and Advanced Education in General Dentistry; Head, Division of Pediatric
Dentistry, D.M.D., National University of Iran,
Ph.D., University of Connecticut Health Center. Development of the
mandibular arch including the elongation and polarized outgrowth of the
mandibular primordia and subsequent differentiation of the skeletal
tissues in spatially defined patterns. Characterization of genetic and
epigenetic influences involved in the pattern formation and
skeletogenesis of the chick mandible and mouse tooth germ. Regulation of
patterning in the developing mandible and developing teeth by mandibular
epithelium, extracellular matrix molecules, growth factors, and
transcription factors.
William A.
Mohler, Ph.D., Assistant Professor of Genetics and Developmental
Biology. Developmental cell fusion; C. elegans genetics;
multidimensional imaging of developmental and cell biological processes.
D. Kent Morest,
M.D., Professor of Neuroscience. Role of cell and tissue interactions in
the migration and differentiation of neurons; structure and function of
neurons during development and synapse formation.
John J. Peluso,
Professor of Cell Biology, Ph.D., West Virginia University, 1974.
Hormonal control of ovarian follicular growth and atresia (apoptosis);
characterization of a putative membrane receptor for progesterone.
Ernst
Reichenberger, Assistant Professor of Oral Rehabilitation,
Biomaterials and Skeletal Development, Center for Regenerative Medicine
and Skeletal Development.
Ph.D., University of Erlangen. The Reichenberger laboratory is
interested in learning about the complex processes required for
generating and maintaining the skin and bones. To find out how the
mechanisms operate in a healthy person, we study human genetic disorders
in which they are disrupted.
David Rowe,
M.D., Professor of Genetics and Developmental Biology. Hormonal
regulation of Type I collagen in mature and developing bone; heritable
disorders of bone formation.
Linda Shapiro,
Assistant Professor of Cell Biology; Ph.D., University of Michigan
1984. To dissect and analyze the regulation of tissue-restricted gene
expression, my laboratory has concentrated on understanding the
molecular mechanisms controlling transcription of the CD13/APN gene in
hematopoietic cells and more recently, in angiogenic endothelium.
Petros
Tsipouras, M.D., Professor of Pediatrics. Heritable disorders of
connective tissue, nosology, and genetics; genetic linkage studies;
molecular mechanisms of mutations in human collagen genes.
William B. Upholt, Ph.D.,
Professor of Oral Rehabilitation, Biomaterials and Skeletal Development,
Center for Regenerative Medicine and Skeletal Development; Director,
Skeletal, Craniofacial and Oral Biology Graduate Program. Regulation of gene
expression during embryonic development; procollagen gene expression and
regulation in limb chondrogenesis and skeletogenesis; pattern formation;
homeobox genes.
Anthony T. Vella,
Assistant Professor of Medicine, Ph.D. Cornell University.
Characterizing peripheral T cell tolerance versus long-term immunity.
Charles
Wolgemuth, Assistant Professor of Cell Biology; Ph.D. University of
Arizona. My research objectives deal with using physics to understand
biological systems. My main interests lie in morphology, propulsion,
growth and fluid dynamics.
Nada Zecevic,
Assistant Professor of Neuroscience, M.D., Ph.D., University of
Belgrade, Yugoslavia. Cellular and
molecular aspects of CNS development; primate cerebral cortex; microglia;
multiple sclerosis. |
