Ph.D. in Biomedical Science: Thematic Research Areas
Cell Biology, Cell Signaling, and Pharmacology
Rashmi Bansal,
Associate Professor of Neuroscience; Ph.D., Central Drug Res. Institute,
1976. The developmental, cellular and molecular biology of
oligodendrocytes (OLs).
Elisa Barbarese,
Professor of Neuroscience, Ph.D., McGill University.
Developmental neurobiology, myelination, and multiple sclerosis.
Choukri Ben
Mamoun, Ph.D., Associate Professor of Genetics and Developmental
Biology. Cell signaling and transport of nutrients in the human malaria
parasite plasmodium falciparum.
Stefan Brocke, Assistant Professor, M.D., Ph.D., Cellular
and molecular mechanisms of brain injury in inflammatory and
inflammation-associated disorders of the central nervous system.
Gordon G.
Carmichael, Professor of Genetics and Developmental Biology; Ph.D.,
Harvard, 1975. Regulation of gene expression in eukaryotes.
Joan M. Caron, Assistant Professor of Cell Biology;
Ph.D., University of Connecticut.
Biochemical, cell
biological and genetic approaches to examine the function of
microtubules, and to identify new anti-microtubule drugs for use against
cancer.
John H. Carson, Professor of Molecular,
Microbial and Structural Biology, B.A., Reed College, Ph.D.,
Massachusetts Institute of Technology. RNA transport in cells of the
nervous system.
Kevin Claffey,
Associate Professor of Cell Biology; Ph.D., Boston University School of
Medicine, 1989. Angiogenesis in cancer progression and metastasis;
Vascular endothelial growth factor (VEGF) expression; Hypoxia-mediated
gene regulation.
Robert B. Clark,
Associate Professor of Immunology, M.D., Stanford, 1975. Autoimmunity;
immune regulation; regulatory T cells.
Ann
Cowan, Associate Professor of Molecular, Microbial and Structural
Biology; Deputy Director, Center for Biomedical Imaging Technology;
Ph.D., University of Colorado, 1984 Research encompassing several areas
of mammalian sperm development.
Stephen J. Crocker, Assistant
Professor of Neuroscience, Ph.D., University of Ottowa.
Stem cells; glia; metalloproteinases; cytokines; development; pathology;
tissue culture.
Asis K. Das,
Professor of Molecular, Microbial and Structural Biology, B.Sc., M.Sc.,
Ph.D. University of Calcutta.
Genetics, genomics and
mechanisms of bacterial adaptive response; genetic control of
bacteriophage lysogeny and lysis; and non-coding RNAs in prokaryotic
development.
Caroline N.
Dealy, Ph.D., Associate Professor of Oral Rehabilitation,
Biomaterials and Skeletal Development, Center for Regenerative Medicine
and Skeletal Development.
The molecular regulation of limb
development in the vertebrate embryo, from early stages where the limb
is initially formed, to limb patterning and outgrowth, to skeletogenesis.
Anne Delany,
Assistant Professor of Medicine. Ph.D. Dartmouth Medical School. Study
of non-collagenous matrix proteins and metalloproteinases important in
bone remodeling. This includes investigation of the function and
post-transcriptional regulation of osteonectin or SPARC in bone, and the
function and regulation of the metastasis associated metalloproteinase,
stromelsyin-3, in bone.
Kimberly Dodge-Kafka,
Assistant Professor of Cell Biology/Center for Cardiology and
Cardiovascular Research; Ph.D., University of
Texas Health Science Center-Houston, 1999. Molecular
mechanism of signaling pathways in the heart.
David I. Dorsky, Assistant Professor of Medicine, Division of
Infectious Diseases; M.D., Ph.D., Harvard, 1976.
Anti-HIV and anti-herpesvirus
drug mechanisms, herpesviral DNA polymerases, gene transfer strategies
applied to bioengineering and studies of antigen presentation.
Betty Eipper,
Professor of Cell Biology and Neuroscience, B.S., M.S., Brown University,
Ph.D., Harvard University. Biosynthesis and secretion of peptides by
neurons and endocrine cells.
Paul Epstein,
Ph.D., Associate Professor of Cell Biology. Receptor signal
transduction, second messengers, and protein phosphorylation in control
of cell growth and regulation; purification and regulation of cyclic
nucleotide phosphodiesterases; role of calmodulin in mediating Ca2+-dependent
cell processes.
Min Fang,
M.D., Ph.D., Assistant Professor of
Genetics and Developmental Biology. The
role of early growth response gene 1 (EGR1) in tumorigensis.
Alan
Fein, Professor of Cell Biology; Ph.D., Johns Hopkins, 1973.
Molecular basis of visual excitation and adaptation.
Maurice B.
Feinstein, Professor of Cell Biology; Ph.D., SUNY Downstate Medical
Center, 1960. Role of blood platelet proteins in thromboembolic diseases
(e.g., heart attack, stroke).
Guo-Hua Fong, Assistant Professor of Cell Biology, Ph.D., University
of Illinois. Developmental biology of the vascular system, VEGF-A
receptor signal transduction, embryonic stem cells and gene knock-out in
mice.
A. Jon Goldberg, Professor of Prosthodontics, Director of the Center
for Biomaterials, Ph.D. University of Michigan. Biomaterials,
with studies involving structure-property relationships, development of
novel systems, clinical evaluations and surface analysis.
Brenton R. Graveley, Associate Professor of Genetics and
Developmental Biology. Ph.D. University of Vermont, 1996. Regulation of
alternative pre-mRNA splicing.
Gloria
Gronowicz, Professor and Director of Orthopaedic Research,
Department of Orthopaedics, Ph.D., Columbia University. Effects of
hormones and growth factors on the production of extracellular matrix (ECM)
proteins, on the regulation of integrins (receptors for ECM proteins)
and on apoptosis in bone; response of bone cells to implant
biomaterials.
Arthur Günzl, Ph.D., Associate Professor of Genetics and
Developmental Biology and Center for Microbial Pathogenesis.
Transcription and Antigenic Variation in the mammalian parasite
Trypanosoma brucei.
David
Han, Assistant Professor of Cell Biology, Ph.D., Washington
University, 1994. Apoptosis signaling using proteomics and mass
spectrometry and bioinformatics technologies.
Arthur R. Hand, Professor of Orthodontics and Maxillofacial Surgery,
Pediatric Dentistry and Advanced Education in General Dentistry,
Division of Pediatric Dentistry, D.D.S., University
of California, Los Angeles. Study of gene expression in rodent salivary
glands during normal growth and development and in various experimental
conditions employing morphological, immunological and biochemical
methodology.
Christopher Heinen, Assistant
Professor of Medicine, B.Sc., Northwestern University, Ph.D., University
of Cincinnati. Biochemical and cellular defects of the DNA
mismatch repair pathway during tumorigenesis.
James Hewett,
Assistant Professor of Neuroscience, Ph.D., Michigan State University.
Mechanisms of cell injury and inflammation in the central nervous system.
Sandra Hewett,
Associate Professor of Neuroscience, B.S., Providence College, Ph.D.,
Michigan State University. Mechanisms underlying cell death in the
central nervous system: the interplay between excitotoxicity and
inflammation.
Timothy Hla,
Professor of Cell Biology; Ph.D., George Washington University, 1988.
Molecular mechanisms of angiogenesis, G-protein-coupled receptor
signaling, Cyclooxygenase (Cox-2) and cancer, lipid mediators.
Chi-Kuang Huang, Associate Professor of Immunology, B.S., National
Taiwan University; M.Phil., Ph.D., Yale University. Signal transduction
in stimulated neutrophil and lymphocytes, roles of protein kinase and
phosphoproteins in cell activation; chemotaxis.
Marja Hurley, Professor of Medicine, M.D., University of Connecticut
School of Medicine. Molecular mechanisms by which members of the fibroblast growth factor (FGFs)
and fibroblast growth factor receptor (FGFR) families, (produced by
osteoblasts, osteoclasts and stromal cells) regulate bone development,
remodeling and disorders of bone. Fgf2 knockout and Fgf2 transgenic mice
are utilized in loss and gain of function experiments to elucidate the
role of FGF-2 in disorders of bone including osteoporosis.
Laurinda A. Jaffe, Professor of Cell Biology; Ph.D., UCLA, 1977. The
cell biology of fertilization, and the regulation of meiosis in oocytes.
Ingela Jansson, Assistant Professor of Cell Biology, Ph.D., DNA-binding proteins in metallothionine induction and Cytochrome
P450-cytochrome b5 interactions.
Stephen M. King,
Professor of Molecular, Microbial and Structural Biology; Ph.D.,
University College, London, 1982. Cell Biology, Structure and Function
of Molecular Motors, Dynein biochemistry and Cell Biology, Structural
Biology.
Lawrence A. Klobutcher,
Professor of Molecular, Microbial and Structural Biology, B.S., Loyola
University (Chicago), Ph.D., Yale University. DNA rearrangement in
eukaryotic cells.
Dennis E. Koppel, Professor of Biochemistry; Ph.D., Columbia, 1973.
Application of biophysical techniques to membrane dynamics; mechanisms
by which specialized cell-surface domains are produced and maintained.
Leo
Lefrancois, Professor of Immunology, B.S., Colorado State
University; Ph.D., Wake Forest University. T-cell activation and
migration, T-cell memory; immune response to infection; tolerance;
vaccines.
Eric S. Levine, Assistant Professor of Neuroscience, B.S.,
Massachusetts Institute of Technology, Ph.D., Princeton University.
Synaptic physiology and plasticity, in particular the roles of nerve
growth factors and endogenous cannabinoids in the hippocampus and
cerebral cortex.
Bruce Liang, Professor of Medicine, M.D., Harvard Medical School,
1982. Signal transduction, cardiac and vascular cell biology,
receptors, G proteins, transgenic mice.
Leslie M. Loew,
Professor of Cell Biology; Ph.D., Cornell, 1974. Spectroscopic methods
for measuring spatial and temporal variations in membrane potential;
electric field effects on cell membranes; membrane pores induced by
toxins and antibiotics.
Sanjay Mallya,
Assistant Professor of Oral Health and Diagnostic Sciences, Division of
Oral Diagnosis, B.D.S., M.D.S., University of
Bombay; Ph.D., University of Connecticut. Molecular genetics of oral
cancer, Effects of parathyroid hormone on bone.
Nilanjana Maulik,
Associate Professor of Surgery; Ph.D., University of
Calcutta, 1990. Molecular and Cellular signaling during myocardial
ischemia and reperfusion.
Bruce J. Mayer,
Associate Professor of Genetics and Developmental Biology, Ph.D.
Rockefeller University, Mechanisms of signal transduction.
William A.
Mohler, Ph.D., Assistant Professor of Genetics and Developmental
Biology. Developmental cell fusion; C. elegans genetics;
multidimensional imaging of developmental and cell biological processes.
D. Kent Morest,
M.D., Professor of Neuroscience. Role of cell and tissue interactions in
the migration and differentiation of neurons; structure and function of
neurons during development and synapse formation.
Bijay
Mukherji, Professor of Medicine, M.D., Calcutta University. Tumor
immunology and cancer vaccines, tumor-specific antigens.
Douglas L. Oliver,
Professor of Neuroscience, Ph.D., Duke University.
Synaptic organization; Parallel information processing in the central
nervous system; Ionic currents and channel expression and their role in
information processing; Neurocytology, morphology, and cellular
physiology of CNS sensory systems; Biology of hearing and deafness.
Flavia A. O'Rourke, Assistant Professor of Pharmacology; Ph.D.,
Connecticut, 1976. Signal transduction in human platelets with specific
interest in the inositol phosphate signaling pathway and its regulation.
Joel S. Pachter, Professor of
Cell Biology; Ph.D., NYU, 1983. Use of laser capture microdissection for
gene profiling of the neurovascular unit in health and disease.
Achilles J.
Pappano, Professor of Cell Biology, B.S., St. Joseph's
College, Ph.D., University of Pennsylvania.
Development of autonomic innervation and of autonomic neuroeffector
transmission in the embryonic chick heart.
John J. Peluso,
Professor of Cell Biology, Ph.D., West Virginia University, 1974.
Hormonal control of ovarian follicular growth and atresia (apoptosis);
characterization of a putative membrane receptor for progesterone.
Carol C. Pilbeam, Professor of Medicine; PhD., Yale University,
1982. M.D., Yale School of Medicine. Mechanisms of regulation of bone
formation and resorption.
Ernst
Reichenberger, Assistant Professor of Oral Rehabilitation,
Biomaterials and Skeletal Development, Center for Regenerative Medicine
and Skeletal Development.
Ph.D., University of Erlangen. The Reichenberger laboratory is
interested in learning about the complex processes required for
generating and maintaining the skin and bones. To find out how the
mechanisms operate in a healthy person, we study human genetic disorders
in which they are disrupted.
Vladimir
Rodionov, Assistant Professor of Cell Biology; Ph.D., Moscow State
University, 1980. Research in this laboratory is focused on molecular
mechanisms of intracellular transport and organization of microtubule
cytoskeleton.
Daniel W.
Rosenberg, Ph.D., Professor of Medicine. Molecular genetics of
colorectal cancer; signaling pathways in the development of tumors; toxicogenomics
Mansoor Sarfarazi, Ph.D., Professor of Surgery. Positional Mapping
and Mutation Analysis of Human Genetic Disorders; Primary Open Angle
Glaucoma, Primary Congenital Glaucoma, Synpolydactyly, Dyslexia, Mitral
Valve Prolapse and Ascending Aortic Aneurysm.
John B.
Schenkman, Professor of Cell Biology; Ph.D., SUNY Upstate Medical
Center, 1964. Isolation and characterization of cytochrome P450 forms in
mammalian tissues, mechanism of action of cytochrome P450,
protein-protein interaction in the monoxygenase reaction.
Martin R.
Schiller, Assistant Professor of Neuroscience. Ph.D., Utah State
University. Spinal cord injury, neuronal morphology, peptide
neurotransmitters, secretory pathway.
Linda Shapiro,
Assistant Professor of Cell Biology; Ph.D., University of Michigan
1984. To dissect and analyze the regulation of tissue-restricted gene
expression, my laboratory has concentrated on understanding the
molecular mechanisms controlling transcription of the CD13/APN gene in
hematopoietic cells and more recently, in angiogenic endothelium.
Henry Smilowitz,
Professor of Radiology, Ph.D., Massachusetts Institute of Technology.
Development of novel therapies for
experimental advanced, imminently lethal malignant brain tumors in rats
and mice; Use of gold nanoparticles to develop a new form of radiation
therapy (gold-enhanced radiation therapy) and novel approaches to both
tumor and vascular imaging.
Pramod K.
Srivastava, Professor of Medicine, Ph.D., Center for Cellular &
Molecular Biology, Hyderabad, India. Heat shock proteins as peptide
chaperones, roles in antigen presentation and applications in
immunotherapy of cancer, infectious diseases and autoimmune disorders.
Mark R. Terasaki,
Associate Professor of Cell Biology, Ph.D., University of California,
Berkeley, 1983. Mechanism of
nuclear envelope breakdown; structure and function of the endoplasmic
reticulum
Jennifer
Tirnauer, Assistant Professor of Medicine/Center for Molecular
Medicine; M.D., University of Maryland School of Medicine, 1989. Role of
the microtubule cytoskeleton in cancer biology; molecular mechanisms of
microtubule regulation.
Hung Ton-That,
Assistant Professor of Molecular, Microbial & Structural
Biology, B.S., Ph.D., University of California, Los Angeles. Pilus
assembly and sortase-mediated anchoring of surface proteins in
Gram-positive bacteria.
James Watras,
Associate Professor of Medicine; Ph.D., Washington State, 1979. The
mechanisms by which the sarcoplasmic reticulum regulates intracellular
calcium concentration in vascular smooth muscle.
Bruce A. White, Professor of Cell
Biology; Ph.D., Berkeley, 1980. Aspects of prolactin and growth hormone
gene expression in the rat pituitary and rat pituitary tumor cell lines.
Charles
Wolgemuth, Assistant Professor of Cell Biology; Ph.D. University of
Arizona. My research objectives deal with using physics to understand
biological systems. My main interests lie in morphology, propulsion,
growth and fluid dynamics.
Catherine H. Wu,
Professor of Medicine; Ph.D., CUNY, Brooklyn, 1976. Molecular control
mechanisms involved in the regulation of collagen synthesis at a
molecular level.
George Y. Wu,
Professor of Medicine; M.D./Ph.D., Yeshiva (Einstein), 1976. Use of
receptor-mediated endocytosis as a natural mechanism for targeting
substances to specific cell-types.
Lixia Yue, Assistant Professor of
Cell Biology, Center for Cardiology and Cardiovascular Biology; Ph.D.,
McGill University, 1999. TRP channels and Ca2+ signaling mechanisms;
Physiological and pathological functions of TRP channels in heart,
brain, and kidney.
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