Ph.D. in Biomedical Science: Thematic Research Areas
Cancer Biology and Molecular Medicine
Andrew Arnold, M.D., Professor of Medicine and Genetics &
Developmental Biology, Murray-Heilig Chair in Molecular Medicine,
Director, Center for Molecular Medicine. Pathogenesis
of parathyroid and other endocrine tumors, and role of the cyclin D1
oncogene in neoplasia, including breast cancer.
Gordon G.
Carmichael, Professor of Genetics and Developmental Biology; Ph.D.,
Harvard, 1975. Regulation of gene expression in eukaryotes.
Kevin Claffey,
Associate Professor of Cell Biology; Ph.D., Boston University School of
Medicine, 1989. Angiogenesis in cancer progression and metastasis;
Vascular endothelial growth factor (VEGF) expression; Hypoxia-mediated
gene regulation.
Anne Delany,
Assistant Professor of Medicine. Ph.D. Dartmouth Medical School. Study
of non-collagenous matrix proteins and metalloproteinases important in
bone remodeling. This includes investigation of the function and
post-transcriptional regulation of osteonectin or SPARC in bone, and the
function and regulation of the metastasis associated metalloproteinase,
stromelsyin-3, in bone.
Paul Epstein,
Ph.D., Associate Professor of Cell Biology. Receptor signal
transduction, second messengers, and protein phosphorylation in control
of cell growth and regulation; purification and regulation of cyclic
nucleotide phosphodiesterases; role of calmodulin in mediating Ca2+-dependent
cell processes.
Min Fang,
M.D., Ph.D., Assistant Professor of
Genetics and Developmental Biology. The
role of early growth response gene 1 (EGR1) in tumorigensis.
Guo-Hua Fong, Assistant Professor of Cell Biology, Ph.D., University
of Illinois. Developmental biology of the vascular system, VEGF-A
receptor signal transduction, embryonic stem cells and gene knock-out in
mice.
Henry M. Furneaux, Associate Professor of Molecular, Microbial and
Structural Biology; Ph.D., University of Aberdeen, Scotland. The
regulation of gene expression at the posttranscriptional level.
Brenton R. Graveley, Associate Professor of Genetics and
Developmental Biology. Ph.D. University of Vermont, 1996. Regulation of
alternative pre-mRNA splicing.
David
Han, Assistant Professor of Cell Biology, Ph.D., Washington
University, 1994. Apoptosis signaling using proteomics and mass
spectrometry and bioinformatics technologies.
Marc Hansen, Professor of Medicine, M.S., University of Wisconsin
1982, Ph.D. University of Cincinnati College of Medicine 1986. Molecular
genetics of osteosarcoma and related bone diseases.
Christopher Heinen, Assistant
Professor of Medicine, B.Sc., Northwestern University, Ph.D., University
of Cincinnati. Biochemical and cellular defects of the DNA
mismatch repair pathway during tumorigenesis.
Timothy Hla,
Professor of Cell Biology; Ph.D., George Washington University, 1988.
Molecular mechanisms of angiogenesis, G-protein-coupled receptor
signaling, Cyclooxygenase (Cox-2) and cancer, lipid mediators.
Marja Hurley, Professor of Medicine, M.D., University of Connecticut
School of Medicine. Molecular mechanisms by which members of the fibroblast growth factor (FGFs)
and fibroblast growth factor receptor (FGFR) families, (produced by
osteoblasts, osteoclasts and stromal cells) regulate bone development,
remodeling and disorders of bone. Fgf2 knockout and Fgf2 transgenic mice
are utilized in loss and gain of function experiments to elucidate the
role of FGF-2 in disorders of bone including osteoporosis.
Liisa T. Kuhn,
Assistant Professor of Oral Rehabilitation, Biomaterials and Skeletal
Development, Center for Regenerative Medicine and Skeletal Development. Ph.D., University of
California-Santa Barbara. Biomaterials for drug delivery and bone
regeneration and repair.
Leo
Lefrancois, Professor of Immunology, B.S., Colorado State
University; Ph.D., Wake Forest University. T-cell activation and
migration, T-cell memory; immune response to infection; tolerance;
vaccines.
Zihai (Zack) Li,
Associate Professor of Immunology, M.D., Henan Medical College, Ph.D.,
Mount Sinai School of Medicine. Tumor immunology, roles of heat shock
proteins and heat shock response in antigen presentation, T cell
education and anti-tumor immunity.
Alan G. Lurie, Head and Professor of Oral and Maxillofacial Radiology, D.D.S., UCLA, Ph.D., University of Rochester. Digital imaging analysis of
dental and bone diseases.
Sanjay Mallya,
Assistant Professor of Oral Health and Diagnostic Sciences, Division of Oral Diagnosis, B.D.S., M.D.S., University of
Bombay; Ph.D., University of Connecticut. Molecular genetics of oral
cancer, Effects of parathyroid hormone on bone.
Bruce J. Mayer,
Associate Professor of Genetics and Developmental Biology, Ph.D.
Rockefeller University, Mechanisms of signal transduction.
Bijay
Mukherji, Professor of Medicine, M.D., Calcutta University. Tumor
immunology and cancer vaccines, tumor-specific antigens.
Carol C. Pilbeam, Professor of Medicine; PhD., Yale University,
1982. M.D., Yale School of Medicine. Mechanisms of regulation of bone
formation and resorption.
Daniel W.
Rosenberg, Ph.D., Professor of Medicine. Molecular genetics of
colorectal cancer; signaling pathways in the development of tumors; toxicogenomics
Linda Shapiro,
Assistant Professor of Cell Biology; Ph.D., University of Michigan
1984. To dissect and analyze the regulation of tissue-restricted gene
expression, my laboratory has concentrated on understanding the
molecular mechanisms controlling transcription of the CD13/APN gene in
hematopoietic cells and more recently, in angiogenic endothelium.
Henry Smilowitz,
Professor of Radiology, Ph.D., Massachusetts Institute of Technology.
Development of novel therapies for
experimental advanced, imminently lethal malignant brain tumors in rats
and mice; Use of gold nanoparticles to develop a new form of radiation
therapy (gold-enhanced radiation therapy) and novel approaches to both
tumor and vascular imaging.
Pramod K.
Srivastava, Professor of Medicine, Ph.D., Center for Cellular &
Molecular Biology, Hyderabad, India. Heat shock proteins as peptide
chaperones, roles in antigen presentation and applications in
immunotherapy of cancer, infectious diseases and autoimmune disorders.
Jennifer
Tirnauer, Assistant Professor of Medicine/Center for Molecular
Medicine; M.D., University of Maryland School of Medicine, 1989. Role of
the microtubule cytoskeleton in cancer biology; molecular mechanisms of
microtubule regulation.
Bruce A. White, Professor of Cell
Biology; Ph.D., Berkeley, 1980. Aspects of prolactin and growth hormone
gene expression in the rat pituitary and rat pituitary tumor cell lines.
Changping Zou, Associate Professor
of Molecular, Microbial and Structural Biology, Ph.D., University of
Texas, Houston, M.D., Beijing Medical University. Molecular biology of
gynecologic cancers with a focus on signaling pathways and biomarkers
involved in chemoprevention. |
