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Thematic Research Areas:
Host-Pathogen Interactions and Immunology Research

 

Host-Pathogen Interactions and Immunology research areas include understanding fundamental aspects of immune function such as the regulation of autoimmunity, cancer immunology and immune responses to infectious agents such as bacteria and viruses. There is also considerable interest in understanding how pathogens replicate and subvert host defenses.


Adam J. Adler, Professor of Immunology, B.S., McGill University, Ph.D., Columbia University. Our lab studies mechanisms of T cell tolerization to peripheral self-antigens, as well as the relationship between tolerance and tumor immunity.

Hector Leo Aguila, Associate Professor of Immunology, Ph.D., Albert Einstein College of Medicine. Hematopoiesis and bone marrow microenvironment; lymphoid cell development; stem cell biology.

Stefan Brocke, Assistant Professor, M.D., Ph.D., Cellular and molecular mechanisms of brain injury in inflammatory and inflammation-associated disorders of the central nervous system.

Robert B. Clark, Professor of Immunology, M.D., Stanford, 1975. Autoimmunity; immune regulation; regulatory T cells.

Stephen J. Crocker, Assistant Professor of Neuroscience, Ph.D., University of Ottowa. Stem cells; glia; metalloproteinases; cytokines; development; pathology; tissue culture.

Asis K. Das, Professor of Molecular, Microbial and Structural Biology, B.Sc., M.Sc., Ph.D., University of Calcutta. Genetics, genomics and mechanisms of bacterial adaptive response; genetic control of bacteriophage lysogeny and lysis; and non-coding RNAs in prokaryotic development.

Patricia I. Diaz, Assistant Professor, Ph.D., The University of Adelaide. Inter-species interactions in oral microbial communities that determine oral biofilm formation. Shifts in the oral microbiome composition associated with oral diseases such as mucositis during cancer chemotherapy and periodontal diseases. Interaction of oral microbial communities with the host.

Anna Dongari-Bagtzoglou, Professor of Periodontology, D.D.S., Aristotle University, Greece, M.S., University of California, Los Angeles, Ph.D., University of Texas, San Antonio. Pathogenesis of oral opportunistic infections in the immunocompromised host. Regulation of oral mucosal inflammation in response to bacterial or fungal infection. Innate immune factors which limit oral mucosal infection and invasion.

David I. Dorsky, Associate Professor of Medicine, Division of Infectious Diseases; M.D., Ph.D., Harvard, 1976. Anti-HIV and anti-herpesvirus drug mechanisms, herpesviral DNA polymerases, gene transfer strategies applied to bioengineering and studies of antigen presentation.

Paul Epstein, Ph.D., Associate Professor of Cell Biology. Receptor signal transduction, second messengers, and protein phosphorylation in control of cell growth and regulation; purification and regulation of cyclic nucleotide phosphodiesterases; role of calmodulin in mediating Ca2+-dependent cell processes.

Joel S. Pachter, Professor of Cell Biology; Ph.D., NYU, 1983. Use of laser capture microdissection for gene profiling of the neurovascular unit in health and disease.

Lynn Puddington, Associate Professor of Immunology, B.S., Iowa State University, Ph.D., Wake Forest University. Allergic asthma; neonatal immunity and tolerance; developmental immunology.

Justin D. Radolf, Professor of Medicine and Center for Microbial Pathogenesis, M.D., University of California-San Francisco. Molecular pathogenesis and immunobiology of spirochetal infections.

Pramod K. Srivastava, Professor of Medicine, Ph.D., Center for Cellular and Molecular Biology, Hyderabad, India. Heat shock proteins as peptide chaperones, roles in antigen presentation and applications in immunotherapy of cancer, infectious diseases and autoimmune disorders.

Anthony T. Vella, Professor of Immunology, Ph.D., Cornell University. T-cell immunity; costimulation; adjuvants and cytokines.

Sandra K. Weller, Professor of Molecular, Microbial and Structural Biology, B.S., Stanford University, Ph.D., University of Wisconsin. Molecular genetics and biochemistry of herpes simplex virus DNA replication.

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