Thematic Research Areas:
Host-Pathogen Interactions and
Immunology Research
Host-Pathogen Interactions and Immunology research areas
include understanding fundamental aspects of immune function
such as the regulation of autoimmunity, cancer immunology and
immune responses to infectious agents such as bacteria and
viruses. There is also considerable interest in understanding
how pathogens replicate and subvert host defenses.
Adam J. Adler, Associate Professor of Immunology, B.S.,
McGill University, Ph.D., Columbia University. Our lab studies
mechanisms of T cell tolerization to peripheral self-antigens,
as well as the relationship between tolerance and tumor
immunity.
Hector Leo
Aguila, Assistant Professor of Immunology, Ph.D.,
Albert Einstein College of Medicine. Hematopoiesis and bone
marrow microenvironment; lymphoid cell development; stem cell
biology.
Stefan Brocke, Assistant Professor, M.D., Ph.D., Cellular and
molecular mechanisms of brain injury in inflammatory and
inflammation-associated disorders of the central nervous system.
Robert B. Clark, Associate Professor of Immunology, M.D.,
Stanford, 1975. Autoimmunity; immune regulation; regulatory T
cells.
Stephen J. Crocker, Assistant Professor of Neuroscience,
Ph.D., University of Ottowa. Stem cells; glia;
metalloproteinases; cytokines; development; pathology; tissue
culture.
Asis K. Das, Professor of Molecular, Microbial and Structural
Biology, B.Sc., M.Sc., Ph.D., University of Calcutta. Genetics,
genomics and mechanisms of bacterial adaptive response; genetic
control of bacteriophage lysogeny and lysis; and non-coding RNAs
in prokaryotic development.
Patricia I. Diaz,
Assistant Professor, Ph.D., The University of Adelaide.
Inter-species interactions in oral microbial communities that
determine oral biofilm formation. Shifts in the oral microbiome
composition associated with oral diseases such as mucositis
during cancer chemotherapy and periodontal diseases. Interaction
of oral microbial communities with the host.
Anna Dongari-Bagtzoglou, Assistant Professor of
Periodontology, D.D.S., Aristotle University, Greece, M.S.,
University of California, Los Angeles, Ph.D., University of
Texas, San Antonio. Pathogenesis of oral opportunistic
infections in the immunocompromised host. Regulation of oral
mucosal inflammation in response to bacterial or fungal
infection. Innate immune factors which limit oral mucosal
infection and invasion.
David I. Dorsky, Assistant Professor of Medicine, Division of
Infectious Diseases; M.D., Ph.D., Harvard, 1976. Anti-HIV and
anti-herpesvirus drug mechanisms, herpesviral DNA polymerases,
gene transfer strategies applied to bioengineering and studies
of antigen presentation.
Paul Epstein, Ph.D., Associate Professor of Cell Biology.
Receptor signal transduction, second messengers, and protein phosphorylation in control of cell growth and regulation;
purification and regulation of cyclic nucleotide
phosphodiesterases; role of calmodulin in mediating
Ca2+-dependent cell processes.
Irving Goldschneider, Professor of Immunology, B.A., M.D.,
University of Pennsylvania. T and B cell development; acquired
thymic tolerance; cytokines.
Leo Lefrançois, Professor of Immunology, B.S., Colorado State
University; Ph.D., Wake Forest University. T-cell activation and
migration, T-cell memory; immune response to infection;
tolerance; vaccines.
Bijay Mukherji, Professor of Medicine, M.D., Calcutta
University. Tumor immunology and cancer vaccines, tumor-specific
antigens.
Joel S. Pachter, Professor of Cell Biology; Ph.D., NYU, 1983.
Use of laser capture microdissection for gene profiling of the
neurovascular unit in health and disease.
Lynn Puddington, Associate Professor of Immunology, B.S.,
Iowa State University, Ph.D., Wake Forest University. Allergic
asthma; neonatal immunity and tolerance; developmental
immunology.
Justin D. Radolf, Professor of Medicine and Center for
Microbial Pathogenesis, M.D., University of California-San
Francisco. Molecular pathogenesis and immunobiology of
spirochetal infections.
Pramod K. Srivastava, Professor of Medicine, Ph.D., Center
for Cellular and Molecular Biology, Hyderabad, India. Heat shock
proteins as peptide chaperones, roles in antigen presentation
and applications in immunotherapy of cancer, infectious diseases
and autoimmune disorders.
Jason M. Tanzer, Professor and Division Head of Oral
Medicine, Department of Oral Diagnosis, School of Dental
Medicine; also, Professor of Clinical Microbiology, Department
of Laboratory Medicine, School of Medicine. D.M.D., Tufts
University School of Dental Medicine; Ph.D., Georgetown
University; D.H.C. Sahlgrenska Academy at the University of
Gothenburg, Sweden. 1. The physiological/biochemical/genetic
bases of virulence by the mutans streptococci (Streptococcus
mutans) and its colonization of the teeth and the
physiological/biochemical/genetic bases of non-virulence of
Streptococcus gordonii despite its avid colonization of the
teeth. 2. The colonization determinants of certain
HIV-inhibiting Lactobacillus species in the
oral-gastro-intestinal tract.
Roger S. Thrall, Professor of Immunology, B.A., Eastern
Connecticut State College; Ph.D., Marquette University and
Medical College of Wisconsin. Immune cells, pulmonary
inflammation.
Anthony T. Vella, Assistant Professor of Immunology, Ph.D.,
Cornell University. T-cell immunity; costimulation; adjuvants
and cytokines.
Sandra K. Weller, Professor of Molecular, Microbial and
Structural Biology, B.S., Stanford University, Ph.D., University
of Wisconsin. Molecular genetics and biochemistry of herpes
simplex virus DNA replication.
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