Thematic Research Areas:
Host-Pathogen Interactions and
Host-Pathogen Interactions and Immunology research areas
include understanding fundamental aspects of immune function
such as the regulation of autoimmunity, cancer immunology and
immune responses to infectious agents such as bacteria and
viruses. There is also considerable interest in understanding
how pathogens replicate and subvert host defenses.
Adam J. Adler, Professor of Immunology, B.S.,
McGill University, Ph.D., Columbia University. Our lab studies
mechanisms of T cell tolerization to peripheral self-antigens,
as well as the relationship between tolerance and tumor
Aguila, Associate Professor of Immunology, Ph.D.,
Albert Einstein College of Medicine. Hematopoiesis and bone
marrow microenvironment; lymphoid cell development; stem cell
Stefan Brocke, Assistant Professor, M.D., Ph.D., Cellular and
molecular mechanisms of brain injury in inflammatory and
inflammation-associated disorders of the central nervous system.
Robert B. Clark, Professor of Immunology, M.D.,
Stanford, 1975. Autoimmunity; immune regulation; regulatory T
Stephen J. Crocker, Assistant Professor of Neuroscience,
Ph.D., University of Ottowa. Stem cells; glia;
metalloproteinases; cytokines; development; pathology; tissue
Asis K. Das, Professor of Molecular, Microbial and Structural
Biology, B.Sc., M.Sc., Ph.D., University of Calcutta. Genetics,
genomics and mechanisms of bacterial adaptive response; genetic
control of bacteriophage lysogeny and lysis; and non-coding RNAs
in prokaryotic development.
Patricia I. Diaz,
Assistant Professor, Ph.D., The University of Adelaide.
Inter-species interactions in oral microbial communities that
determine oral biofilm formation. Shifts in the oral microbiome
composition associated with oral diseases such as mucositis
during cancer chemotherapy and periodontal diseases. Interaction
of oral microbial communities with the host.
Anna Dongari-Bagtzoglou, Professor of Periodontology, D.D.S., Aristotle University, Greece, M.S.,
University of California, Los Angeles, Ph.D., University of
Texas, San Antonio. Pathogenesis of oral opportunistic
infections in the immunocompromised host. Regulation of oral
mucosal inflammation in response to bacterial or fungal
infection. Innate immune factors which limit oral mucosal
infection and invasion.
David I. Dorsky,
Associate Professor of Medicine, Division of
Infectious Diseases; M.D., Ph.D., Harvard, 1976. Anti-HIV and
anti-herpesvirus drug mechanisms, herpesviral DNA polymerases,
gene transfer strategies applied to bioengineering and studies
of antigen presentation.
Paul Epstein, Ph.D., Associate Professor of Cell Biology.
Receptor signal transduction, second messengers, and protein phosphorylation in control of cell growth and regulation;
purification and regulation of cyclic nucleotide
phosphodiesterases; role of calmodulin in mediating
Ca2+-dependent cell processes.
Joel S. Pachter, Professor of Cell Biology; Ph.D., NYU, 1983.
Use of laser capture microdissection for gene profiling of the
neurovascular unit in health and disease.
Lynn Puddington, Associate Professor of Immunology, B.S.,
Iowa State University, Ph.D., Wake Forest University. Allergic
asthma; neonatal immunity and tolerance; developmental
Justin D. Radolf, Professor of Medicine and Center for
Microbial Pathogenesis, M.D., University of California-San
Francisco. Molecular pathogenesis and immunobiology of
Pramod K. Srivastava, Professor of Medicine, Ph.D., Center
for Cellular and Molecular Biology, Hyderabad, India. Heat shock
proteins as peptide chaperones, roles in antigen presentation
and applications in immunotherapy of cancer, infectious diseases
and autoimmune disorders.
Anthony T. Vella, Professor of Immunology, Ph.D.,
Cornell University. T-cell immunity; costimulation; adjuvants
Sandra K. Weller, Professor of Molecular, Microbial and
Structural Biology, B.S., Stanford University, Ph.D., University
of Wisconsin. Molecular genetics and biochemistry of herpes
simplex virus DNA replication.