Thematic Research Areas: Development and Differentiation
Hector Leo
Aguila, Assistant Professor of Immunology, Ph.D., Albert
Einstein College of Medicine. Hematopoiesis and bone marrow
microenvironment; lymphoid cell development; stem cell biology.
Rashmi Bansal,
Associate Professor of Neuroscience; Ph.D., Central Drug
Research Institute, 1976. The developmental, cellular and
molecular biology of oligodendrocytes (OLs).
Elisa Barbarese, Professor of Neuroscience, Ph.D., McGill
University. Developmental neurobiology, myelination, and
multiple sclerosis.
John H. Carson, Professor of Molecular, Microbial and
Structural Biology, B.A., Reed College, Ph.D., Massachusetts
Institute of Technology. RNA transport in cells of the nervous
system.
Stormy J.
Chamberlain, Assistant Professor of Genetics and
Developmental Biology. Ph.D., University of Florida. Human
induced pluripotent stem (iPS) cell models to study 15q11-q13
imprinting disorders.
Stephen J. Crocker, Assistant Professor of Neuroscience,
Ph.D., University of Ottowa. Stem cells; glia;
metalloproteinases; cytokines; development; pathology; tissue
culture.
Caroline N. Dealy,
Ph.D., Associate Professor of Oral Rehabilitation, Biomaterials
and Skeletal Development, Center for Regenerative Medicine and
Skeletal Development. Regulation of articular cartilage
differentiation and homeostasis by matrix and growth factors;
genetic control of skeletal development and regeneration; stem
cells for repair or regeneration of cartilage or limb tissue;
stem cells as models for cartilage disease .
Hicham Drissi, Associate Professor of Orthopaedic Surgery.
Ph.D., Universite Paris V. Molecular pathways of bone and cartilage
repair.
Paul Epstein, Ph.D., Associate Professor of Cell Biology.
Receptor signal transduction, second messengers, and protein phosphorylation in control of cell growth and regulation;
purification and regulation of cyclic nucleotide
phosphodiesterases; role of calmodulin in mediating
Ca2+-dependent cell processes.
Guo-Hua Fong, Assistant Professor of Cell Biology, Ph.D.,
University of Illinois. Developmental biology of the vascular
system, VEGF-A receptor signal transduction, embryonic stem
cells and gene knock-out in mice.
Brenton R. Graveley, Professor of Genetics and
Developmental Biology. Ph.D., University of Vermont, 1996.
Regulation of alternative pre-mRNA splicing.
Gloria Gronowicz,
Professor in the Department of Surgery with a secondary
appointment in Orthopaedics, Ph.D., Columbia University.
Projects: 1) Response of bone cells to implant biomaterials, 2)
the effect of the human biofield, through Therapeutic Touch, on
normal cells and breast cancer cells, and 3) otosclerosis.
Arthur R. Hand, Professor of Craniofacial Sciences and Cell
Biology, D.D.S., University of California, Los Angeles. Study of
protein and gene expression in rodent salivary glands during
normal growth and development and in various experimental
conditions employing morphological, immunological and
biochemical methodology.
Marc Hansen, Professor of Medicine, M.S., University of
Wisconsin 1982, Ph.D. University of Cincinnati College of
Medicine 1986. Molecular genetics of osteosarcoma and related
bone diseases.
Marja Hurley, Professor of Medicine, M.D., University of
Connecticut School of Medicine. Molecular mechanisms by which
members of the fibroblast growth factor (FGFs) and fibroblast
growth factor receptor (FGFR) families, (produced by osteoblasts,
osteoclasts and stromal cells) regulate bone development,
remodeling and disorders of bone. Fgf2 knockout and Fgf2
transgenic mice are utilized in loss and gain of function
experiments to elucidate the role of FGF-2 in disorders of bone
including osteoporosis.
Laurinda A. Jaffe, Professor of Cell Biology; Ph.D., UCLA,
1977. The cell biology of fertilization, and the regulation of
meiosis in oocytes.
Barbara Kream, Ph.D., Professor of Medicine and Genetics and
Developmental Biology. Hormonal regulation of bone remodeling.
Marc Lalande, Ph.D., Professor and Head of Genetics and
Developmental Biology. Epigenetics including the control of gene
expression in embryonic carcinoma stem cells and genomic
imprinting and its association with neurogenetics disorders.
Leo Lefrançois, Professor of Immunology, B.S., Colorado State
University; Ph.D., Wake Forest University. T-cell activation and
migration, T-cell memory; immune response to infection;
tolerance; vaccines.
James Li, Ph.D., Assistant Professor. Development of the
central nervous system (CNS), with an emphasis on the mammalian
cerebellum.
Xuejun (June) Li, Assistant Professor of Neuroscience, Ph.D., Fudan University. Stem cells; neural development and
degeneration.
Alexander Lichtler, Ph.D., Associate Professor of Genetics
and Developmental Biology. Regulation of collagen gene
transcription; retrovirus vectors; role of homeobox genes in
limb development.
Mina Mina, Professor of Orthodontics and Maxillofacial
Surgery, Pediatric Dentistry and Advanced Education in General
Dentistry; Head, Division of Pediatric Dentistry, D.M.D.,
National University of Iran, Ph.D., University of Connecticut
Health Center. Development of the mandibular arch including the
elongation and polarized outgrowth of the mandibular primordia
and subsequent differentiation of the skeletal tissues in
spatially defined patterns. Characterization of genetic and
epigenetic influences involved in the pattern formation and
skeletogenesis of the chick mandible and mouse tooth germ.
Regulation of patterning in the developing mandible and
developing teeth by mandibular epithelium, extracellular matrix
molecules, growth factors, and transcription factors.
William A. Mohler, Ph.D., Assistant Professor of Genetics and
Developmental Biology. Developmental cell fusion; C. elegans
genetics; multidimensional imaging of developmental and cell
biological processes.
D. Kent Morest, M.D., Professor of Neuroscience. Role of cell
and tissue interactions in the migration and differentiation of
neurons; structure and function of neurons during development
and synapse formation.
John J. Peluso, Professor of Cell Biology, Ph.D., West
Virginia University, 1974. Hormonal control of ovarian
follicular growth and atresia (apoptosis); characterization of a
putative membrane receptor for progesterone.
Ernst Reichenberger, Assistant Professor of Oral
Rehabilitation, Biomaterials and Skeletal Development, Center
for Regenerative Medicine and Skeletal Development. Ph.D.,
University of Erlangen. The Reichenberger laboratory is
interested in learning about the complex processes required for
generating and maintaining the skin and bones. To find out how
the mechanisms operate in a healthy person, we study human
genetic disorders in which they are disrupted.
David W. Rowe, Professor of Reconstructive Sciences,
Director of Center for Regenerative Medicine and Skeletal
Development, M.D., University of Vermont.
Identification and
characterization of cells within the mesenchymal lineages that
lead to formation and maintenance skeletal tissues. Murine
models for assessing cell based therapies for regeneration of
adult skeletal structures.
Linda Shapiro, Assistant Professor of Cell Biology; Ph.D.,
University of Michigan 1984. To dissect and analyze the
regulation of tissue-restricted gene expression, my laboratory
has concentrated on understanding the molecular mechanisms
controlling transcription of the CD13/APN gene in hematopoietic
cells and more recently, in angiogenic endothelium.
William B. Upholt, Ph.D., Professor of Oral Rehabilitation,
Biomaterials and Skeletal Development, Center for Regenerative
Medicine and Skeletal Development; Director, Skeletal,
Craniofacial and Oral Biology Graduate Program. Regulation of
gene expression during embryonic development; procollagen gene
expression and regulation in limb chondrogenesis and
skeletogenesis; pattern formation; homeobox genes.
Anthony T. Vella, Assistant Professor of Medicine, Ph.D.,
Cornell University. Characterizing peripheral T cell tolerance
versus long-term immunity.
Charles Wolgemuth,
Associate Professor of Cell Biology; Ph.D., University of
Arizona. My research focuses on determining the physical
underpinnings of biological processes. My primary interests lie
in determining how forces are produced inside cells in order to
handle processes such as creating and maintaining cell shape,
and driving cell motility and cell growth. Some areas of
research include wound healing, cancer metastatsis, and
pathogen-host interactions during Lyme disease.
Nada Zecevic, Assistant Professor of Neuroscience, M.D.,
Ph.D., University of Belgrade, Yugoslavia. Cellular and
molecular aspects of CNS development; primate cerebral cortex;
microglia; multiple sclerosis.
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