Skeletal Biology and Regeneration Graduate Program
Douglas J. Adams, Assistant Professor of Orthopaedic
Surgery. Ph.D., University of Iowa. Consequences of
early return to high-demand activities following immobility on
bone and joint tissue injuries, recovery, and pathology.
Arnold, Professor of Medicine and Murray-Heilig Chair in
Molecular Medicine, M.D., Harvard University. The molecular
genetic underpinnings of tumors of the endocrine glands. Role of
cyclin D1 in tumorigenesis.
Associate Professor; Ph.D., Wesleyan University. Research interests are
complex human disorders using stem cell technology, functional genomics
and animal models to understand chromatin architecture and epigenetic
Ernesto Canalis, Professor of Orthopaedic Surgery and
Medicine, M.D., Universidad Peruana Cayetano Heredia. Skeletal
growth factors, insulin-like growth factors, hormonal action in
bone, mechanisms of glucocorticoid action in bone, and anabolic
agents and osteoporosis.
I-Ping Chen, Assistant Professor, Oral Health and Diagnostic
Sciences, D.D.S., PhD., UConn Health.
Generation of induced pluripotent stem (iPS) cells from
craniometaphyseal dysplasia (CMD) patients and investigation of
osteoclast biology in the human stem cell system as well as in
CMD mouse models.
Justin Cotney, Assistant Professor, Ph.D. Emory
University. Determining how gene regulatory elements, namely enhancers,
control gene expression during mammalian development.
Caroline N. Dealy, Associate Professor of Reconstructive
Sciences, Center for Regenerative Medicine and Skeletal
Development. Ph.D., University of Connecticut. Regulation of
articular cartilage differentiation and homeostasis by matrix
and growth factors; genetic control of skeletal development and
regeneration; stem cells for repair or regeneration of cartilage
or limb tissue; stem cells as models for cartilage disease.
Associate Professor of Medicine. Ph.D., Dartmouth College.
Regulation of osteoblast and osteoclast gene expression by
microRNAs; Molecular mechanisms controlling bone remodeling.
Diaz, Assistant Professor, Ph.D., The University of
Adelaide. Inter-species interactions in oral microbial
communities that determine oral biofilm formation. Shifts in the
oral microbiome composition associated with oral diseases such
as mucositis during cancer chemotherapy and periodontal
diseases. Interaction of oral microbial communities with the
Anna Dongari-Bagtzoglou, Professor, Department of
Oral Health and Diagnostic Sciences, Division of Periodontology,
D.D.S., Aristotle University, Greece, M.S., University of
California, Los Angeles, Ph.D., University of Texas, San
Antonio. Pathogenesis of oral opportunistic infections in the
immunocompromised host. Regulation of oral mucosal inflammation
in response to bacterial or fungal infection. Innate immune
factors which limit oral mucosal infection and invasion.
Professor of Orthopaedic Surgery.
Ph.D., Universite Paris V. Molecular pathways of bone and cartilage
Associate Professor of Cell Biology; Ph.D., Albert Einstein
College of Medicine. Targeting the cAMP signaling pathway for
treatment of leukemia and breast cancer.
Marion Frank, Professor of Oral Health and Diagnostic
Sciences; Director, Center for Neurosciences, Ph.D., Brown
University. Study of the sense of taste using basic and clinical
research. Development of a fundamental understanding of
gustatory systems in mammals, at all levels from receptors to
cerebral cortex. Application of basic knowledge of gustatory
systems to the diagnosis and treatment of taste disorders in
A. Jon Goldberg, Professor of Reconstructive Sciences,
Center for Regenerative Medicine and Skeletal Development,
Ph.D., University of Michigan. Biomaterials, with studies
involving structure-property relationships, development of novel
systems, clinical evaluations and surface analysis.
Rosaria Guzzo, Assistant Professor, Ph.D. University of Ottowa.
Identification of key epigenetic mechanisms that modulate the
cartilage-forming potential of human iPS cells.
Arthur R. Hand, Professor of Craniofacial Sciences and Cell
Biology, D.D.S., University of California, Los Angeles. Study of
protein and gene expression in rodent salivary glands during
normal growth and development and in various experimental
conditions employing morphological, immunological and
Marc Hansen, Professor of Medicine, M.S., University of
Wisconsin, Ph.D., University of Cincinnati College of Medicine.
Molecular genetics of osteosarcoma and related bone diseases.
Marja Hurley, Professor of Medicine, M.D., University of
Connecticut School of Medicine. Molecular mechanisms by which
members of the fibroblast growth factor (FGFs) and fibroblast
growth factor receptor (FGFR) families, (produced by osteoblasts,
osteoclasts and stromal cells) regulate bone development,
remodeling and disorders of bone. Fgf2 knockout and Fgf2
transgenic mice are utilized in loss and gain of function
experiments to elucidate the role of FGF-2 in disorders of bone
Associate Professor, Department of Reconstructive
Sciences and Department of Genetics and Developmental Biology.
M.D., Ph.D., University of Zagreb School of Medicine, Croatia. Bone
biology, differentiation of the osteoblast lineage cells.
Yusuf Khan, Assistant Professor of Orthopaedic Surgery and
Chemical, Materials and Biomolecular Engineering. Ph.D. Drexel
University. Strategies to synthesize scaffolds that are also
capable of delivering proteins and growth factors essential for
complete and adequate healing of bone defects through the use of
biodegradable polymers alone and in combination with ceramic
Barbara Kream, Professor of Medicine and Genetics and
Developmental Biology. Ph.D., Yale University. Hormonal
regulation of bone remodeling.
Liisa T. Kuhn,
Associate Professor of Reconstructive
Sciences, Center for Regenerative Medicine and Skeletal
Development. Ph.D., University of California-Santa Barbara.
Biomaterials for drug delivery and bone regeneration and repair.
Kumbar, Assistant Professor of Orthopaedic Surgery,
Ph.D., Karnatak University. Synthesis and characterization of
novel biomaterials/polymers for tissue engineering and drug
Marc Lalande, Professor and Head, Department of Genetics and
Developmental Biology. Ph.D., University of Toronto. Genomic
imprinting of human chromosome 15q.
Cato Laurencin, M.D., Ph.D., University Professor,
Van Dusen Distinguished Endowed Professor of Orthopaedic
Surgery, Professor of Craniofacial Sciences, Professor of
Chemical and Biomedical Engineering and Materials Science.
Regenerative Engineering using biomaterials, stem cells,
physics, and developmental biology.
Associate Professor of Medicine, Ph.D., University of
Connecticut. Osteoclast biology and molecular and cellular
regulation by cytokines in osteoclastogenesis.
Alexander Lichtler, Associate Professor of Genetics and
Developmental Biology, Ph.D., University of Florida, Gainsville.
Hormone regulation of bone collagen synthesis.
Alan G. Lurie, Professor of Oral Health and Diagnostic
Sciences; Head, Division of Oral and Maxillofacial Radiology,
D.D.S., UCLA, Ph.D., University of Rochester. Digital imaging
analysis of dental and bone diseases.
Peter Maye, Assistant Professor of Reconstructive Sciences,
Ph.D., Wesleyan University. Isolation, characterization and
differentiation of embryonic and adult skeletal stem cells down
the osteogenic lineage.
Professor of Craniofacial Sciences, Division of Pediatric
Dentistry. D.M.D., National University of Iran, Ph.D.,
University of Connecticut. Origin, maintenance,
proliferation and differentiation of adult stem cells in dental
Assistant Professor of Orthopaedic Surgery and Chemical,
Materials and Biomolecular Engineering, Ph.D., SCTIMST, India.
Design and development of regenerative biomaterials to favorably
modulate the responses of a variety of cell types involved in
tissue regeneration and repair.
Syam P. Nukavarapu, Assistant
Professor of Orthopaedic Surgery; Chemical, Materials and Biomolecular
Engineering. Ph.D., Indian Institute of Science (IISc). Scaffold based
bone tissue engineering.
Carol C. Pilbeam, Professor of Medicine; Ph.D., Yale
University, 1982. M.D., Yale School of Medicine. Mechanisms of
regulation of bone formation and resorption.
Professor of Reconstructive Sciences, Center for Regenerative
Medicine and Skeletal Development. Ph.D., University of
Erlangen. Our laboratory is interested in the complex
processes required for generating and maintaining skin and
bones. We study rate human genetic disorders where such
mechanisms are disrupted on a genetic and functional level from
gene discovery to in vitro and in vivo models.
Blanka Rogina, Associate Professor of Genetics and
Developmental Biology, Ph.D., Zagreb University School of
Medicine. Biology of aging including the molecular genetic
determinants of aging and longevity.
David W. Rowe, Professor of Reconstructive Sciences,
Director of Center for Regenerative Medicine and Skeletal
Development, M.D., University of Vermont.
characterization of cells within the mesenchymal lineages that
lead to formation and maintenance skeletal tissues. Murine
models for assessing cell based therapies for regeneration of
adult skeletal structures.
Archana Sanjay, Assistant Professor of Orthopaedic Surgery,
School of Medicine, Ph.D.
Regulation of bone remodeling; examining signaling pathways that
regulate osteoblast and osteoclast differentiation and function.