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Molecular Biology and Biochemistry Graduate Program

Research Area Images

 

Nucleic Acids Biochemistry

schematic summary of macronuclear development in E. crassus

Shown is a schematic summary of macronuclear development in E. crassus. Macronuclear-destined sequences are shown as black rectangles, telomeres as hatched boxes, and IESs as ovals – see Lawrence Klobutcher.

 

Structural Biology

image of a recent NMR solution structure

Shown is the recent NMR solution structure of the human XRCC1 NTD repair protein (left, 1xna at the PDB) and a mechanism for interaction with a human DNA polymerase beta-DNA complex (right, 1bpy at the PDB).

 

Computational Biology and Biophysics

image of p16 protein

The p16 protein is a cyclin dependent protein kinase inhibitor and a tumor suppressor. The p16 structure (1BI7 from the PDB) consists of four ankyrin repeats. Based on a computational analysis (bottom image) of the autonomous folding units in p16, a C-terminal fragment (p16C) in red containing only two ankyrin repeats (top image) has been identified and shown by expression cloning, fragment production, and biophysical characterization, to fold into a native-like structure. The plot shows the Z-score (the higher the better for predicted complete folding) for all possible peptide fragments that have the Y-axis value as the N-terminal residue of the fragment and the X-axis value as the C-terminal residue.

 

Protein Biochemistry

model of the protein architecture of the outer dynein arm

Model of the protein architecture of the outer dynein arm showing approximate positions of constituent light chains (LCs) and intermediate chains (ICs) – see Stephen King.

 

Cell Biology

expression of Connexin 32-GFP fusion protein in oligodendrocytes

Expression of Connexin 32-GFP fusion protein in oligodendrocytes. Oligodendrocytes in culture were microinjected with RNA encoding a Cx32-GFP fusion protein. The expressed protein was visualized by confocal microscopy. The red indicates the distribution of Texas Red dextran that was co-injected as a cytoplasmic marker. The green indicates the distribution of Cx32-GFP fusion protein in numerous small clusters throughout the cell. Experimental details are described in Tedford et al. (1997) – see John Carson.

 

Microbial Physiology/Pathogenesis

colocalization by immunofluorescence of a major vegetative cell chromosomal protein

Colocalization by immunofluorescence of a major vegetative cell chromosomal protein (HBsu) with major spore DNA binding proteins (SASP) in the developing spore (shown by the arrow)  of Bacillus subtilis – see Peter Setlow.

  
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