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Faculty
 Changping Zou
Associate Professor, Molecular, Microbial & Structural Biology
Department of Obstetrics/Gynecology, Gynecology/Oncology
zou@uchc.edu
Areas of Interest:
My primary research interest is chemoprevention of gynecologic cancers,
which has a focus on elucidating signaling pathways involved in the
preventive effect of natural and synthetic compounds in ovarian,
cervical, and bladder cancers. My laboratory is studying the genetic
alterations in gynecologic malignancies and the signaling pathways in
response of chemopreventive agents. My study involves using the genetic
alterations and the expression profile of specific genes as biomarkers
to develop early detection methods and prevention approaches against
gynecologic cancers in laboratory research and in chemoprevention
trials.
Since development of an animal model to mimic a human disease allows
experimentation in a strictly controlled laboratory environment in which
experimental subjects can be manipulated in ways that can never be done
in humans, animal models of ovarian cancer, cervical cancer and bladder
cancers have been developed in my laboratory and used in our
chemoprevention studies. Using the animal models, we have tested and
evaluated the effect of different chemopreventive agents on suppressing
initiation and development of ovarian and bladder cancers, and our
findings will help discover new agents and new drug delivery methods in
prevention of ovarian cancer and bladder cancer.
Recently, there has been increasing evidence supporting the hypothesis
that cancer stem cell plays an important role in cancer development. Our
laboratory is currently also working on isolating and characterizing
ovarian cancer stem cells, which may be a key to develop new strategies
of ovarian cancer prevention.
Selected Publications:
Molly Brewer, James Ranger-Moore, William Satterfield, Zengping Hao,
Jian Wang, Emily Brewer, J. Taylor Wharton, Robert Bast, David
Gershenson, and Changping Zou. Combination of 4-HPR and Oral
Contraceptive in Monkey Model of Chemoprevention of Ovarian Cancer.
Frontiers in Biosciences, Front Biosci. 1;12:2260-2268, 2007.
Bast RC Jr, Brewer M, Zou C, Hernandez MA, Daley M, Ozols R, Lu K, Lu Z,
Badgwell D, Mills GB, Skates S, Zhang Z, Chan D, Lokshin A, Yu Y.
Prevention and early detection of ovarian cancer: mission impossible?
Recent Results Cancer Res.174:91-100, 2007.
Changping Zou, Molly Brewer, Xianyi Cao, Jean M Feugang, Jian Wang,
Rongyu Zang, Jianxin Lin, Yuanjian Deng, and Chun Li. Antitumor Activity
of 4-(N-Hydroxyphenyl) Retinamide Conjugated with Poly(L-Glutamic Acid)
Against Ovarian Cancer Xenografts. Gyn Onc-Sept, 2007.
Molly Brewer, Nathaniel D. Kirkpatrick, J. Taylor Wharton, Jian Wang,
Kenneth Hatch, Nelly Auersperg, Robert Bast, Urs Utzinger, Changping Zou.
4-HPR Modulate Gene Expression in Ovarian Cells. Intl J Cancer
119(5):1005-1013, 2006.
Changping Zou, Sanjay Ramakumar, Changchun Zou, Rongyu Zang, Jian
Wang, Lixin Qian, H. Barton Grossman, Reuben Lotan, and Monica Liebert.
Effect of retinoic acid and interferon alpha-2a on transitional cell
carcinoma of bladder. J Urol 173:247-251, 2005.
Molly Brewer, J. Taylor Wharton, Jian Wang, Nelly Auersperg, David
Gershenson, Robert Bast, and Changping Zou. In vitro model of normal,
immortalized ovarian surface epithelium cells and ovarian cancer cells
for chemoprevention of ovarian cancer. Gynecol Oncol 98(2):182-92, 2005.
Da-ming Zou, Molly Brewer, Francisco Garcia, Jean M Feugang, Jian Wang,
Roungyu Zang, and Changping Zou. Cactus Pear - a Natural Product in
Cancer Chemoprevention. Nutr J 4(1):25, 2005.
Zou, CP, Liebert M, Zou CC, Grossman HB, and Lotan R. Identification
of effective retinoids for inhibition growth and inducing apoptosis in
bladder cancer cells. J Urol 165:986-92, 2001.
Zou, CP, Zou CC, Carey TE, and Lotan, R. Differential effect of
chromosome 3p deletion on the expression of the putative tumor
suppressor RAR-and retinoid resistance in human squamous carcinomas
cells. Oncogene 20:6820-7, 2001.
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