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Faculty George Y. Wu
Professor of Medicine
wu@nso.uchc.edu
Use of receptor-mediated endocytosis as a natural mechanism for
targeting substances to specific cell-types.
- Targeted gene delivery for correction of genetic metabolic
disorders.
- Development of antisense and ribozyme strategies for treatment of
viral diseases.
- Modification of viruses to alter infection specificity.
Selected Publications:
Wu, C.H., Sapozhnikov, E., and Wu, G.Y.: Evaluation of multicomponent
non-viral vectors for liver directed gene delivery. J. Drug Target.
10(2), 105-111, (2002).
Smith, R.M., and Wu, G.Y.: Secondary structure and hybridization
accessibility of hepatitis C virus 3'-terminal sequences. J. Virol.
76:9563-9574 (2002).
Wu, C.H., Ouyang, E.C., Walton, C.M. and Wu, G.Y. Human hepatocytes
transplanted into genetically immunocompetent rats are susceptible to
infection by hepatitis B virus in situ. J. Viral Hepatitis 8:111-119
(2001).
Ouyang, E.C., Wu, C.H., Walton, C.M., Promrat, K., and Wu, G.Y.:
Transplantation of human hepatocytes into tolerized genetically
immunocompetent rats. Wld. J. Gastro. 7:324-330 (2001).
Wu, G.Y. Walton, CM, and Wu, CH: Targeted polynucleotides for
inhibition of hepatitis B and C viruses. Croat. Med J. 42:463-466
(2001).
Wu, C.H., Ouyang, E.C., Walton, C.M and Wu, G.Y.: Liver cell
transplantation. Novel model for human hepatic viral infections. Croat.
Med J. 42: 446-450 (2001).
Walton, C.M., Wu, C.H., and Wu, G.Y.: A ribonuclease H-oligo DNA
conjugate that specifically cleaves hepatitis B viral messenger RNA.
Bioconj. Chem. 12:770-775 (2001).
Fukuma, T. Wu, G.Y., and Wu, C.H.: Liver-selective nucleic acid
targeting using the asialoglycoprotein receptor. Gene Ther Reg 1:79-94
(2000).
Wu, C.H and Wu, G.Y.: Gene therapy applications in gastroenterology
and hepatology. Can J. Gastroenterology 14:57-61 (2000).
Promrat, K., Wu, G.Y. and Wu, C.H.: Gene therapy for metabolic
diseases of the liver. BioDrugs 13:177-188 (2000).
Wu, C.H., Walton, C.M. and Wu, G.Y.: Targeted inhibition of type I
procollagen synthesis by antisense DNA oligonucleotides. Gene Ther. and
Reg. 1:193-205 (2000).
Wu, G.Y. Gene therapy: The state of the art. Gastroenterol. Today
4:183-186 (2000).
Smith, R.M. and Wu, G.Y.: Gene therapy for viral hepatitis: Prospects
for the design and delivery of nucleic acid pharmaceuticals. Viral Hep.
Rev. 6:129-141 (2000).
Fukuma, T., Wu, G.Y. and Wu, C.H.: Liver-selective nucleic acid
targeting using the asialoglycoprotein receptor. Gene Ther Reg
1:66-79(2000). |
