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Faculty John D. Shanley
Professor of Medicine
Director, Division of Infectious Diseases
Connecticut State Chair in Infectious Diseases
jshanley@nso1.uchc.edu
The major focus of this laboratory centers on the immunology and
pathogenesis of viral infections. The majority of our work has utilized
murine cytomegalovirus (MCMV), although studies have also involved rat
CMV, human CMV. At present we are focused on two areas: vaccine
modification of host immunity to CMV and the initial host defenses in
viral re-exposure. For the vaccine studies, we have constructed vaccines
expressing specific MCMV genes, using vaccinia virus and a
replication-deficient adenovirus as vectors. The studies of host
responses to virus rechallenge have examined the innate and adaptive
immune responses of the host upon re-infection at a mucosal surface.
Selected Publications:
Shanley, J. D., Wu, C.A. Mucosal Immunzation with a
Replication-Deficient Adenovirus Vector Expressing Murine
Cytomegalovirus glycoprotein B Induces Mucosal and Systemic Immunity.
Vaccine 21:2632-2642, 2003.
Shanley, J. D., Shanley, J. A. Albert, G., Biegel D. Characterization
of Virus Induced IFN-g Responses in Mice Previously Infected With Murine
Cytomegalovirus, J. Infect Dis. 183: 697-706, 2001.
Loh, L., Keeler, V.D., Shanley, J.D. Sequence Requirements for the
nuclear localization of the murine cytomegalovirus M44 gene product
pp50. Virology 259, 43-59, 1999.
Wu CA, Carlson, ME, Henry, SC, Shanley J.D. The murine
cytomegalovirus M25 open reading frame encodes a component of the
tegument. Virology. 262, 265-76, 1999.
Andjelkovic. A.V., Kerkovich, D., Shanley, J.D., Pulliam, L. and
Pachter, J.S. 1999. Expression of binding sites for b chemokines on
human astrocytes. GLIA 28:225-235, 1999. |
