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Faculty Daniel Rosenberg
Professor of Medicine
Investigator, Center for Molecular Medicine
rosenberg@nso2.uchc.edu
Areas of Interest:
We are interested in the molecular mechanisms that regulate tumor
progression in the colon. Our work encompasses the study of signaling
pathways both in mouse tumor models as well as in immortalized cell
lines. A major focus of our research is to use genome-wide profiling to
identify unique patterns of expression and to discover new genes that
predict tumor progression and metastasis.
Lab Rotation Projects:
1. Role of intra- and extracellular phospholipases in the control
of tumorigenesis. Studies on the effects of genetic deletion of
cytoplasmic phospholipase A2 in apoptosis and carcinogenesis initiated
by exposure to tumor initiating events.
2. Gene profiling of adenomas as a means to establish efficacy
of chemoprevention agents in inhibiting cancer cell growth.
3. Genome-wide analysis of chromosomal gains/losses in early
precancerous lesions. Identification of gene polymorphisms as
predisposing factors to cancer risk.
4. Functional analyses of potential tumor suppressors in tumor
cell culture systems.
5. Inflammation driven cancer in the intestine.
6. Mechanisms of tumor cell invasion and metastasis using RNAi
and overexpression of candidate genes.
7. Analysis of the p53-ARF-mdm2 oncogene checkpoint in the
control of tumorigenesis. Analysis of mdm-2 status in tumor cells.
Visit the Center For Molecular Medicine webpage:
http://cmm.uchc.edu/index.html
Selected Publications:
Greenspan EJ, Cyr JL, Pleau DC, Levine J, Rajan TV, Rosenberg DW and
Heinen CD. 2006. Microsatellite instability in aberrant crypt foci from
patients without concurrent colon cancer (Carcinogenesis, in press).
Stevens, RG, Swede, H and Rosenberg, DW. 2006. Epidemiology of colonic
aberrant crypt foci: Review and analysis of existing studies (Cancer
Letters, in press).
Greenspan EJ, Jablonski M, Rajan TV, Levine J, Belinsky GS and Rosenberg
DW. 2006. Epigenetic alterations in RASSF1A in human aberrant crypt
foci. Carcinogenesis 27:1316-22.
Belinsky, GS, Rajan, TV, Saria, E and Rosenberg, DW. 2006. Expression of
secretory phospholipase A2 in colon tumor cells potentiates tumor growth
(Molecular Carcinogenesis, in press).
Flynn, C, Montrose, DC, Swank, DL, Nakanishi, M, Ilsley, JNM and
Rosenberg DW. 2006. Deoxycholic acid promotes the growth of colonic
aberrant crypt foci (Molecular Carcinogenesis, in press).
Mann JR, Backlund MG, Buchanan FG, Daikoku T, Holla VR, Rosenberg DW,
Dey SK and DuBois RN. 2006. Repression of Prostaglandin Dehydrogenase by
EGF and Snail Increases Prostaglandin E-2 and Promotes Cancer
Progression. Cancer Research, 66:6649-6656.
Aizu W, Belinsky GS, Flynn C, Noonan EJ, Boes C, Godman CA, Nambiar PR,
Rosenberg DW and Gardina C. 2006. Circumvention and reactivation of the
p53 oncogene checkpoint in mouse colon tumors Biochemical Pharmacology,
72(8):981-91.
Nakanishi, M and Rosenberg, DW. 2006. Roles of CPLA2-alpha and
arachidonic acid in cancer (review article) Biochem Biophys ACTA,
1761:1335-43.
Stevens RG, Swede, H, Jablonski M, Parente M, Tirnauer JS, Heinen CD,
Giardina C, Rajan TV, Rosenberg DW and Levine J. 2006. Aberrant Crypt
Foci in Persons with a Family History of Colorectal Cancer (Cancer
Letters, Epub, in press).
Kohno M, Momoi M, Oo ML, Paik J-H, Lee Y-M, Venkataraman K, Xi Y,
Ristimaki AP, Fyrst H, Sano H, Rosenberg DW, Saba JD, Proia RL,
Hla T. 2006. An intracellular role for Sphingosine Kinase 1 in
intestinal adenoma cell proliferation. (Molecular Cellular Biology,
26:7211-23.
Belinsky GS, Claffey KP, Nambiar PR, Guda K, Rosenberg DW. 2005.
Vascular endothelial growth factor and enhanced angiogenesis do not
promote metastatic conversion of a newly established azoxymethane-induced
colon cancer cell line. Molecular Carcinogenesis 43(2):65-74.
Tong X, Yin L, Joshi S, Rosenberg DW, Giardina C. 2005. Cyclooxygenase-2
regulation in colon cancer cells: modulation of RNA polymerase II
elongation by HDAC inhibitors. J Biol Chem 22:15503-15509.
Nambiar PR, Boutin, SR, Raja R, Rosenberg DW. 2005. Global gene
expression profiling: a complement to conventional histopathological
analysis of neoplasia. Veterinary Pathology 42:735-752.
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