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Faculty
Blanka Rogina
Assistant Professor of Genetics and Developmental Biology
rogina@neuron.uchc.edu
Research Interest:
The primary interest of our research is the investigation of the
basic biology of aging, including the molecular genetic determinants of
aging and longevity. Over the past few years our work has concentrated
on understanding some of the mechanisms that regulate gene expression
during adult life in Drosophila melanogaster. Currently we are
involved in screening for genes that are involved in life span
determination. Another interest is to investigate the biological
deterinants of female longevity. Female life spans dependents on
reproductive status. It is our goal to study the contribution
reproduction and fertility make toward female longevity.
Selected Publications:
Helfand, S.L. and Rogina, B.: Molecular Genetics of Aging in the Fly:
Is this the End of the Beginning? BioEssays, 25: 1-8, 2003.
Rogina, B., Helfand, S.L. and Frankel S.: "Longevity regulation by
Drosophila Rpd3 deacetylase and caloric restriction", Science,
298:1745, 2002.
Knauf, F*., Rogina, B*., Jiang, Z., Aronson, P. and Helfand, S.L.:
Functional Characterization and Immunolocalization of the Novel
Transporter Encoded by the Life-Extending Gene Indy, Proc. Natl.
Acad. Sci. USA, 99: 14315-14319, 2002. *Theses authors contributed
equally to this work.
Rogina, B., Reenan, R.A., Nilsen, S.P. and Helfand, S.L.: Extended
Life-span Conferred by Cotransporter Gene Mutations in Drosophila,
Science, 290: 2137-2140 2000.
Rogina, B. and Helfand, S.L.: Cu, Zn superoxide dismutase deficiency
accelerates the time course of an age-related marker in Drosophila
melanogaster, Biogerontology, 1: 163-169 2000. |
