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Faculty
 John J. Peluso
Professor of Cell Biology and Obstetrics and Gynecology
peluso@nso2.uchc.edu
Areas of Interest:
Dr. Peluso's laboratory is involved in investigating the cellular and
molecular mechanisms by which hormones and growth factors regulate
ovarian follicular growth, differentiation, and atresia. At present
there are three specific aspects of ovarian function being studied: (1)
The role of cell contact in inhibiting ovarian cell apoptosis, (2) The
identification and characterization of a novel progesterone receptor
that possesses GABAA receptor-like properties and (3) The elucidation of
the mechanism through which steroidogenic factor-1, an orphan nuclear
receptor, negatively regulates mitosis and positively promotes
steroidogenesis. The last project is being conducted in collaboration
with Dr. Bruce White.
Dr. Peluso's Departmental Web Page
Selected Publications:
Peluso JJ: A Multiplicity of Progesterone’s Actions and its Receptors
in the Ovary. Biol Reprod accepted, Jan 2006.
Peluso, JJ, Pappalardo, A, Losel, R and Wehling, M: Progesterone
Membrane Receptor Complex 1 Expression in the Immature Rat Ovary and Its
role in Mediating Progesterone’s Anti-Apoptotic Action. Submitted to
Endocrinology Jan, 2006
Peluso, JJ: N-cadherin mediated cell contact inhibits germinal
vesicle breakdown in mouse oocytes maintained in vitro. Reproduction:
(in press).
Peluso, JJ, Pappalardo, A: Expression and function of PAIRBP within
gonadotopin-primed immatue rat ovaries: PAIRBP regulation of granulosa
and luteal cell viability. Biol Reprod: 73: 261-270, 2005.
Peluso JJ: Rapid Actions of Progesterone on Granulosa Cells. Steroids
69:579-583, 2004.
Peluso, JJ, Pappalardo, A: Progesterone regulates granulosa cell
viability through a protein kinase G-dependent mechanism that involves
14-3-3s. Biol Reprod 71: 1870 - 1878, 2004.
Peluso, JJ, Pappalardo, A, Fernandez, G and Wu, CA: Involvement of an
unnamed protein, RDA288, in the mechanism through which progesterone
mediates its anti-apoptotic action in spontaneously immortalized
granulosa cells. Endocrinology (Feb 26, 2004).
Peluso JJ: Progesterone as a Regulator of Granulosa Cell Viability J
Steroid Biochem Mol Biol 85: 167-173, 2003
Peluso, JJ: Basic fibroblast growth factor regulation of plasma
membrane calcium ATPase as part of an anti-apoptotic mechanism of
action. Biochem Pharm 66: 1363-1369; 2003.
Peluso, JJ, Bremner, T, Fernandez, G, Pappalardo, A, White, BA:
Expression pattern and role of a 60 kDa progesterone binding protein in
regulating granulosa cell apoptosis: Involvement of the MAP kinase
cascade. Biol Reprod 68: 122-128, 2003.
Smith, PM, Heinrich, CA, Pappas, S, Peluso, JJ, Cowan, A, White, BA:
Reciprocal regulation by estradiol17ß of ezrin and cadherin-catenin
complexes in pituitary GH3 cells. Endocrine 17: 219-228, 2002.
Peluso, JJ, Fernandez, G, Pappalardo, A, White, BA:
Membrane-initiated events account for progesterone’s ability to regulate
intracellular free calcium levels and inhibit rat granulosa cell
mitosis. Biol Reprod 67: 379-385, 2002.
Peluso, JJ, Pappalardo, A, Fernandez, G: Basic Fibroblast Growth
Factor Maintains Calcium Homeostasis and Granulosa Cell Viability by
Stimulating Calcium Efflux via a Protein Kinase Cd-Dependent Pathway.
Endocrinology 142: 4203-4211, 2001.
Peluso, JJ, Fernandez, G, Pappalardo, A, White, BA: Characterization
of a putative membrane receptor for progesterone in rat granulosa cells.
Biol Reprod 65: 94-101, 2001.
Peluso, JJ, Pappalardo, A, Fernandez, G: E-cadherin-mediated cell
contact prevents apoptosis of spontaneously immortalized granulosa cells
by regulating Akt kinase activity. Biol Reprod 64: 1183-1190, 2001. |
