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Faculty Mina Mina
Professor of Orthodontics, Oral and Maxillofacial Surgery, Pediatric
Dentistry and Advanced Education
Head, Division of Pediatric Dentistry
Director, Graduate Program in Skeletal, Craniofacial and Oral Biology
Areas of Interest:
One of the major interests of my laboratory has been to elucidate the
mechanisms regulating mandibular outgrowth and morphogenesis with an
emphasis on the roles of signaling factors secreted by mandibular
epithelium. Currently we are focusing on the specific and interactive
roles of two signaling pathways regulated by FGFs and BMPs in the
morphogenesis of the developing mandible.
Second area of interest of my laboratory is signaling pathways
regulating the initial stages of tooth formation. Currently we are
focusing on the possibility of engineering tooth crowns. Towards this
goal, experiments are in progress to examine the multiple
differentiation potentials of dental pulp.
Lab Rotation Projects:
Students with new and innovative ideas about craniofacial and tooth
development are more than welcome to participate in rotation project in
the laboratory. In addition the students can participate in the ongoing
projects in the lab.
The current research projects in the laboratory are:
1. Understanding the mechanisms regulating proper outgrowth and
morphogenesis of mandibular processes.
2. Understanding the differentiation potentials of dental pulp and
its application towards tissue engineering.
Selected Publications:
Savage T, Bennett T, Huang YF, Kelly PL, Durant NE, Adams DJ, Mina M,
Harrison JR. (2006) Mandibular phenotype of p20C/EBPbeta transgenic
mice: Reduced alveolar bone mass and site-specific dentin dysplasia.
Bone. 2006 May 5; [Epub
ahead of print]
Havens BA, Rodgers B, Mina M. (2006) Tissue-specific expression of
Fgfr2b and Fgfr2c isoforms, Fgf10 and Fgf9 in the developing chick
mandible. Arch Oral Biol. 51(2):134-45.
Balic A, Mina M. (2005) Analysis of developmental potentials of
dental pulp in vitro using GFP transgenes. Orthod Craniofac Res. 8(4):252-8.
Bilic-Curcic I, Kronenberg M, Jiang X, Bellizzi J, Mina M,
Marijanovic I, Gardiner EM, Rowe DW. (2005) Visualizing levels of
osteoblast differentiation by a two-color promoter-GFP strategy: Type I
collagen-GFPcyan and osteocalcin-GFPtpz. Genesis. 43(2):87-98.
Jiang X, Kalajzic Z, Maye P, Braut A, Bellizzi J, Mina M, Rowe DW.
(2005)
Histological analysis of GFP expression in murine bone. J Histochem
Cytochem. 53(5):593-602.
Liu F, Woitge HW, Braut A, Kronenberg MS, Lichtler AC, Mina M, Kream
BE. (2004) Expression and activity of osteoblast-targeted Cre
recombinase transgenes in murine skeletal tissues. Int J Dev Biol.
48(7):645-53.
Mina M, Braut A. (2004) New insight into progenitor/stem cells in
dental pulp using Col1a1-GFP transgenes. Cells Tissues Organs.
176(1-3):120-33.
Braut A, Kollar EJ, Mina M. (2003) Analysis of the odontogenic and
osteogenic potentials of dental pulp in vivo using a Col1a1-2.3-GFP
transgene. Int J Dev Biol. 47(4):281-92.
Kalajzic Z, Liu P, Kalajzic I, Du Z, Braut A, Mina M, Canalis. E, and
Rowe D.W. (2002) directing the Expression of GFP transgene in
Differentiated osteoblasts: A comparison between Rat type I Collagen and
Rat Osteocalcin promoters. Bone: 31: 654-660.
Braut A, Kalajzic I, Kalajzic Z, Rowe DW, Kollar ED, and Mina M
(2002) Col1a1-GFP transgene expression in developing incisors. Conn
Tissue Res. 43: 216-219.
Tadic T, Dodig M, Erceg I, Marijanovic I, Mina M, Kalajzic Z, Velonis
D, Kronenberg MS, Kosher RA, Ferrari D, and Lichtler AC (2002).
Overexpression of Dlx5 in chicken calvaria cells accelerates
osteoblastic differentiation. J Bone Miner Res 17: 1008-14.
Mina M, Wang, Y-H, Ivanisevic A-M, and Rodgers B (2002) Region- and
Stage-Specific Effects of FGFs and BMPs in Chick Mandibular
Morphogenesis. Dev. Dyn. 223:333-352
Mina M. (2001). Regulation of mandibular growth and morphogenesis. J.
Craniofac. Genet. Dev. Biol. 12:276-300.
Mina, M. (2001). Morphogenesis of the medial region of the developing
mandible is regulated by multiple signaling pathways. Cells Tissues
Organs, 169: 295-301. |
