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Lisa M. Mehlmann
Assistant Professor of Cell Biology
lmehlmann@neuron.uchc.edu

• Ph.D., Kent State University
• Cell Biology Graduate Program
• Not accepting students for Lab Rotations at this time

Areas of Interest:
I am interested in cell signaling events that regulate oocyte maturation and fertilization. Recently, we have been using cultured mouse ovarian follicles to study the maintenance of meiotic arrest, as well as how luteinizing hormone (LH) overcomes this arrest to signal the oocyte to mature into a fertilized egg. The maintenance of meiotic arrest involves the G-protein coupled receptor, GPR3, that stimulates a Gs G-protein. Gs activation results in an increase in oocyte cAMP, which leads to meiotic arrest. We are examining Gs and GPR3 activity using fluorescently labeled proteins, dominant negative approaches, RNAi, and knockout mice.

Dr. Mehlmann's Departmental Web Page

Selected Publications:

Mehlmann, L.M. 2005. Stops and Starts in Mammalian Oocytes: Recent Advances in Understanding the Regulation of Meiotic Arrest and Oocyte Maturation. Reproduction: 130: 791-798..

Mehlmann, L.M., and Jaffe, L.A. 2005. SH2 domain-mediated activation of a SRC family kinase is not required to initiate Ca2+ release at fertilization in mouse eggs. Reproduction: 129: 557-564.

Freudzon, L., Norris, R.P., Hand, A.R., Tanaka, S., Saeki, Y., Jones, T.L.Z., Rasenick, M.M., Berlot, C.H., Mehlmann, L.M., and Jaffe, L.A. 2005. Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein. J. Cell Biol. 171:255-265.

Mehlmann, L.M. 2005. Oocyte-specific expression of Gpr3 is required for the maintenance of meiotic arrest in mouse oocytes. Dev. Biol. 288:397-404.

Mehlmann, L.M., Saeki, Y., Tanaka, S., Brennan, T.J., Evsikov, A.V. Pendola, F.L., Knowles, B.B., Eppig, J.J., and Jaffe, L.A. 2004. The G_s-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science. 306:1947-50.

Kalinowski, R.R., Berlot, C.H., Jones, T.L.Z., Ross, L.F., Jaffe, L.A., and Mehlmann, L.M. 2004. Maintenance of meiotic prophase arrest in vertebrate oocytes by a G_s protein-mediated pathway. Dev. Biol. 267: 1-13.

Mehlmann, L.M., Jones, T.L.Z., and Jaffe, L.A. 2002. Meiotic arrest in the mouse follicle maintained by a G_s protein in the oocyte. Science 297:1343-1345.

Runft, L.L., Jaffe, L.A., and Mehlmann, L.M. 2002. Egg activation at fertilization: Where it all begins. Dev. Biol. 245:237-254.