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Faculty
 Mark
Maciejewski
Assistant Professor of Molecular, Microbial & Structural Biology
NMR Facility Manager
markm@neuron.uchc.edu
As the NMR Facility Manager I primarily utilize nuclear magnetic
resonance (NMR) to characterize the three dimensional structure,
function and dynamics of proteins from a wide range of biological
systems. Research in our laboratory has focused in the past on enzymes
involved in DNA repair, specifically the base excision repair pathway.
More recently several collaborative projects have been initiated
studying proteins involved in bacterial cell division, neurite
outgrowth, dynein motor complexes, and others. Much future work involve
studying several insecticidal neurotoxins from the African funnel web
spider with potential to be used in insect control in collaboration with
Dr. Glenn King.
NMR Facility
Selected Publications:
Rowland SL, Burkholder WF, Cunningham KA, Maciejewski MW, Grossman
AD, King GF. Structure and mechanism of action of Sda, an inhibitor of
the histidine kinases that regulate initiation of sporulation in
Bacillus subtilis. Mol Cell. 2004,13:689-701.
Wu H, Blackledge M, Maciejewski MW, Mullen GP, King SM.
Relaxation-based structure refinement and backbone molecular dynamics of
the dynein motor domain-associated light chain. Biochemistry. 2003,
42:57-71.
Gryk MR, Marintchev A, Maciejewski MW, Robertson A, Wilson SH, Mullen
GP. Mapping of the interaction interface of DNA polymerase beta with
XRCC1. Structure (Camb). Structure. 2002, 10:1709-20.
Maciejewski MW, Shin R, Pan B, Marintchev A, Denninger A, Mullen MA,
Chen K, Gryk MR, Mullen GP. Solution structure of a viral DNA repair
polymerase. Nat Struct Biol. 2001;8:936-41.
Maciejewski MW, Liu D, Prasad R, Wilson SH, Mullen GP. Backbone
dynamics and refined solution structure of the N-terminal domain of DNA
polymerase beta. Correlation with DNA binding and dRP lyase activity. J
Mol Biol. 2000;296:229-53. |
