|
Faculty Alan G. Lurie
Professor of Oral Health and Diagnostic Sciences
Head, Division of Oral and Maxillofacial Radiology
Director, D.M.D./Ph.D. Combined Degree Program
lurie@nso.uchc.edu
Research activities have been concerned with actions and interactions
of radiation and chemical carcinogens during epithelial carcinogenesis.
Previous studies have included tumor incidence, histopathology,
cytokinetics, chemical induction of tumors, functional hemodynamics, and
carcinogen-DNA interactions. We found that low-level x-radiation
exposures enhance hydrocarbon carcinogenesis, and that radiation- and
carcinogen-induced alterations in microvascular function and in proximal
carcinogen-DNA binding are likely mechanisms.
Ongoing studies are investigating DNA mutagenesis and repair by gamma
radiation in lymphoblasts from both normal and ataxia telangiectatic
humans. We have constructed and are employing extra-chromosomal shuttle
vectors in these studies, which are directed towards analysis of single
base mutations, cell cycle effects, and the induction and
characterization of specific repair proteins following exposures in the
cumulative low-moderate dose range.
Clinical research has been in the laboratory and clinical
applications of nuclear medicine, complex motion tomography and
subtraction radiology to the diagnosis and treatment planning, as well
as basic biologic phenomena, of a variety of dental pathologies,
including healing bone wounds, oral carcinoma, treatment planning of
benign neoplasms of the jaws, salivary gland disorders, and early
crestal bone changes in marginal periodontitis. We also conduct clinical
studies addressing the dosimetry and risk estimations for various TMJ,
implant and intraoral imaging procedures, as well as digital imaging
research.
Selected Publications:
Scholl, RJ, Kellett, HM. Brown, SL, Neumann, DP and Lurie, AL. Cystic
lesions of the mandible: a clinical and radiological-pathcal review. In
Press, Radiographics, 1999.
Scaf, G., Lurie, A.G., Mosier, KM., Kantor, ML., Ramsby, GR. And
Freedman, ML. Dosimetry and cost of imaging osseointegrated implants
with film-based tomography and computed tomography. Oral Surg. 83:41-48,
1997.
Brooks, SL., Brand, J., Gibbs, SJ., Hollender, L., Lurie, AG., Omnell,
KA., White, S. and Westesson, PL. Imaging of the temporomandibular
joint. Oral Surg. 83:609-618, 1997.
Scaf, G, Kantor, ML, Mosier, KM, Ramsby, GR, Lurie, AG and Freedman,
ML, Dosimetry and cost of imaging for osseointegrated implants with
film-based tomography and computed tomography. Oral Surg, 83:41-47,
1997.
Tetradis, S, Scaf, G, Lurie, AG and Freedman, ML, Niobium filtration
of conventional and high frequency X-ray generators: effects on absorbed
doses, image density and contrast, and photon spectra. Oral Surg,
80:232-241, 1995. |
