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Faculty James Li
Assistant Professor
Associate Director, Graduate Program in Genetics and Developmental
Biology
jali@uchc.edu
Areas of interests:
Research in the lab focuses on brain development in mammals, with an
emphasis on the questions of how the identity of neural cell types is
specified and how neurons establish their connections with each other
during normal development. We use mouse genetics combined with
molecular, biochemical and genomic studies to investigate the mechanisms
for normal brain development and the pathology of developmental defects,
which underlie devastating neurological conditions. Furthermore, we
attempt to exploit our knowledge of the developmental control of neural
differentiation to direct differentiation of embryonic stem cells, which
would facilitate our search for new or improved strategies for these
devastating brain disease.
Lab Rotation Projects:
Details of research projects can be found in the following link:
http://www.genetics.uchc.edu/lilab/Pages/Research.html
Selected Publications:
Guo, Q.X. and Li, J.Y.H. (2007). Distinct functions of the major Fgf8
spliceform, Fgf8b, before and during mouse gastrulation. Development
134, 2251-60.
Li, J.Y.H*., Lao, Z., and Joyner, A.L. (2005). New Regulatory
Interactions and Cellular Responses in the Isthmic Organizer Region
Revealed by Altering Gbx2 Expression. Development 132, 1971-81.
(*Corresponding author)
Olsen, S.K., Li, J.Y.H., Bromleigh, V.C., Elseenkova, A.V., Ibrahimi,
O.A., Zhang, F.,Linhardt, R.J., Joyner, A.L., Mohammadi, M. (2005).
Structural Basis for the Modulation of FGF8 Mid-Hindbrain Patterning By
Alternative Splicing. Gene & Development 20, 185-98.
Sparwasser, T., Gong, S., Li, J.Y.H. and Eberl, G. (2003). A General
Method for the Modification of Different BAC Types and the Rapid
Generation of BAC Transgenic Mice. Genesis 38, 39-50.
Liu, A., Li, J.Y.H., Bromleigh, V.C., Lao, Z, Niswander, L.A., and
Joyner, A.L. (2003). FGF17b and FGF18 have different midbrain regulatory
properties from FGF8b or activated FGF Receptors. Development
130, 6175-85.
Li. J. Y.H., Lao, Z., and Joyner, A. L. (2002). Changing requirements
for Gbx2 in development of the cerebellum and maintenance of the
mid/hindbrain organizer. Neuron 36, 31-43.
Li. J. Y.H., and Joyner, A.L. (2001). Otx2 and Gbx2 are required to
define the spatial expression of genes at the mid-hindbrain junction,
not their induction. Development 28, 4979-91. |
