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Faculty Shigeyuki Kuwada
Professor of Neuroscience
shig@neuron.uchc.edu
Areas of Interest: Physiology and anatomy of the mammalian
auditory system. A primary focus of our research is to understand the
neural basis of binaural hearing, with a special emphasis on the
processing of interaural time disparities (ITDs). ITD is a major cue for
localizing sounds along the azimuth. To accomplish this goal, we have
studied binaural processing at each major level along the ascending
auditory pathway, including the superior olivary complex, dorsal nucleus
of the lateral lemniscus, inferior colliculus, auditory thalamus, and
auditory cortex. Since we have shown that anesthesia alters the response
properties of binaural neurons, all of our studies have been conducted
using an unanesthetized rabbit preparation. Our primary technique is to
extracellularly record the responses of neurons to monaural and binaural
sounds, but we have also employed intracellular recording and staining
techniques to examine the synaptic inputs and morphology of binaural
neurons. Another research interest is in the development of a
non-invasive electro-audiometric technique to assess hearing disorders
in newborns and children.
Kuwada Lab Page
Publications
Selected Publications:
D'Angelo WR, Sterbing SJ, Ostapoff EM, Kuwada S. (2003) Effects of
amplitude modulation on the coding of interaural time differences of
low-frequency sounds in the inferior colliculus. II. Neural mechanisms.J
Neurophysiol. Nov;90(5):2827-36.
Sterbing SJ, D'Angelo WR, Ostapoff EM, Kuwada S. (2003) Effects of
amplitude modulation on the coding of interaural time differences of
low-frequency sounds in the inferior colliculus. I. response properties.
J Neurophysiol. Nov;90(5):2818-26.
Fitzpatrick DC, Kuwada S, Batra R. (2002) Transformations in
processing interaural time differences between the superior olivary
complex and inferior colliculus: beyond the Jeffress model. Hear Res.
Jun;168(1-2):79-89.
Kuwada S, Anderson JS, Batra R, Fitzpatrick DC, Teissier N, D'Angelo
WR. (2002) Sources of the scalp-recorded amplitude-modulation following
response. J Am Acad Audiol. Apr;13(4):188-204.
Fitzpatrick DC, Kuwada S. (2001) Tuning to interaural time
differences across frequency. J Neurosci. Jul 1;21(13):4844-51.
Fitzpatrick DC, Kuwada S, Batra R. (2000) Neural sensitivity to
interaural time differences: beyond the Jeffress model. J Neurosci. Feb
15;20(4):1605-15. |
