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Faculty Donald L. Kreutzer
Professor of Pathology and Surgery
kreutzer@nso2.uchc.edu
The research efforts in our laboratory is directed at unraveling the
immunopathology of inflammatory and neoplastic diseases. Specifically,
we are interested in delineating the underlying mediators, modulators
and mechanisms responsible for the initiation, amplification and control
of inflammatory reactions, and the accompanying repair processes, i.e.,
wound healing. Our approach involves a broad research attack which
utilizes many of the diverse areas of immunology (e.g., immunochemistry,
immunobiology, immunopathology), biochemistry, cellular and molecular
biology, in an effort to delineate the role of immune cells and factors
in acute and chronic inflammation. We have focused on delineation of
inflammatory mediators and mechanisms in a variety of specialized
tissues, including eyes, lungs, ear, nasal polyps, skin, joints, as well
as breast, prostate and oral compartments to name but a few. Our efforts
are not only directed at understanding the underlying mechanisms and
results of inflammation in these specialized tissue compartments, but
also to understand common pathways of inflammation and tissue injury
which occur in all tissues. Thus, this diverse approach to understanding
basic inflammatory and neoplastic mechanisms not only provides insights
into disease in specialized tissue, but also provides insights into the
general phenomena of inflammation and cancer, and the common and unique
roles of tissue mediators and regulators (leukocyte chemotactic factors
and inactivators), cell movement and activation, vascular and corneal
endothelial cell biology, coagulation factors fibrin and fibrin
mediated, as well as synthesis and communication play in these diseases.
These investigations involve multi-disciplinary approaches requiring
collaborations between our laboratory and other members of the
immunology graduate program, as well as a number of faculty of both
clinical and basic science departments at the UConn Health Center. Thus,
our research involves a spectrum of basic and clinical investigations
which are focused on developing an understanding of inflammatory
mechanisms and tissue injury which, in turn, can be directly applied to
controlling both inflammation and cancer.
Publications
Selected Publications:
Klueh U, Dorsky DI, Kreutzer DL. Use of vascular endothelial cell
growth factor gene transfer to enhance implantable sensor function in
vivo. J Biomed Mater Res. 2003 Dec 15;67A(4):1072-86. PMID: 14666925 [PubMed
- in process]
Klueh U, Dorsky DI, Moussy F, Kreutzer DL. Ex ova chick
chorioallantoic membrane as a novel model for evaluation of tissue
responses to biomaterials and implants. J Biomed Mater Res. 2003 Dec
1;67A(3):838-43. PMID: 14613232 [PubMed - in process]
Lalla RV, Boisoneau DS, Spiro JD, Kreutzer DL. Expression of vascular
endothelial growth factor receptors on tumor cells in head and neck
squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2003
Aug;129(8):882-8. PMID: 12925349 [PubMed - indexed for MEDLINE]
Pantschenko AG, Pushkar I, Anderson KH, Wang Y, Miller LJ, Kurtzman
SH, Barrows G, Kreutzer DL. The interleukin-1 family of cytokines and
receptors in human breast cancer: implications for tumor progression.
Int J Oncol. 2003 Aug;23(2):269-84. PMID: 12851675 [PubMed - indexed for
MEDLINE]
Pantschenko AG, Pushkar I, Miller LJ, Wang YP, Anderson K, Peled Z,
Kurtzman SH, Kreutzer DL. In vitro demonstration of breast cancer tumor
cell sub-populations based on interleukin-1/tumor necrosis factor
induction of interleukin-8 expression. Oncol Rep. 2003
Jul-Aug;10(4):1011-7. PMID: 12792762 [PubMed - indexed for MEDLINE]
Lalla RV, Tanzer ML, Kreutzer DL. Identification of a region of the
fibrin molecule involved in upregulation of interleukin-8 expression
from human oral squamous cell carcinoma cells. Arch Oral Biol. 2003
Apr;48(4):263-71. PMID: 12663071 [PubMed - indexed for MEDLINE]
Sfakianakis A, Barr CE, Kreutzer DL. Localization of the chemokine
interleukin-8 and interleukin-8 receptors in human gingiva and cultured
gingival keratinocytes. J Periodontal Res. 2002 Apr;37(2):154-60. PMID:
12009185 [PubMed - indexed for MEDLINE]
Miller LJ, Fischer KA, Goralnick SJ, Litt M, Burleson JA, Albertsen
P, Kreutzer DL. Nerve growth factor and chronic prostatitis/chronic
pelvic pain syndrome. Urology. 2002 Apr;59(4):603-8. PMID: 11927336 [PubMed
- indexed for MEDLINE]
Sfakianakis A, Barr CE, Kreutzer DL. Actinobacillus
actinomycetemcomitans-induced expression of IL-1alpha and IL-1beta in
human gingival epithelial cells: role in IL-8 expression. Eur J Oral Sci.
2001 Dec;109(6):393-401. PMID: 11767276 [PubMed - indexed for MEDLINE]
PMID: 11699484 [PubMed - indexed for MEDLINE]
Klueh U, Goralnick S, Bryers JD, Kreutzer DL. Binding and orientation
of fibronectin on surfaces with collagen-related peptides. Student
Research Award in the Masters Science Degree Candidate category, 27th
annual meeting of the Society for Biomaterials, St. Paul, MN, April
24-29, 2001. J Biomed Mater Res. 2001 Sep 5;56(3):307-23. PMID: 11426429
[PubMed - indexed for MEDLINE]
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