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Faculty Robert A. Kosher
Professor of Oral Rehabilitation, Biomaterials and Skeletal Development,
Center for Regenerative Medicine and Skeletal Development
kosher@neuron.uchc.edu
Limb development; roles and relationships among regulatory genes
particularly homeobox-containing genes, secreted signaling molecules,
and the extracellular matrix in the regulation of limb formation,
outgrowth, patterning, cartilage differentiation, osteogenesis, and
joint formation.
Selected Publications:
Ferrari, D. and Kosher, R.A. (2002). Dlx5 is a positive regulator of
chondrocyte differentiation during endochondral ossification. Dev. Biol.
252, 257-270.
Lizarraga, G., Lichtler, A., Upholt, W.B., and Kosher, R.A. (2002).
Studies on the role of Cux1 in regulation of the onset of joint
formation in the developing limb. Dev. Biol 243, 44-54.
Seghatoleslami, M.R., Martinez, A., Cuttitta, F., and Kosher, R.A.
(2002). Distribution and possible function of an adrenomedulllin-like
peptide in the developing chick limb bud. Int. J. Dev. Biol. 46,957-961.
Tadic, T., Dodig, M., Erceg, I., Marijanovic, I., Mina, M., Kalajzic,
Z., Velonis, D., Kronenberg, M.R., Ferrari, D., Kosher, R.A., and
Lichtler, A.C. (2002). Overexpression of Dlx5 in chicken calvarial cells
accelerates osteoblastic differentiation. J. Bone Mineral Res. 17,
1008-1014.
Harrington, A., Dealy, C. N., and Kosher, R. A. (1999). Dlx-5 in limb
initiation in the chick embryo. Developmental Dynamics 216, 10-15.
Lizarraga, G., Ferrari, D., Kalinowsky, M., Ohuchi, H., Noji, S.,
Kosher, R.A., and Dealy, C.N. (1999). FGFR2 signaling in normal and
limbless chick limb buds. Developmental Genetics 25,331-338. |
