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Faculty
 Laurinda A. Jaffe
Professor of Cell Biology
ljaffe@neuron.uchc.edu
Areas of Interest:
My research concerns the cell biology of fertilization, and the
regulation of meiosis in oocytes. Questions of interest include how the
sperm activates the egg to begin development, and how the oocyte matures
to become a fertilization-competent egg. Currently we are investigating
the role of a G-protein-linked receptor, GPR3, in the maintenance of
meiotic prophase arrest in follicle-enclosed mouse oocytes.
Dr. Jaffe's Departmental Web Page
Selected Publications:
Mehlmann, L.M., and Jaffe, L.A. 2005. SH2 domain-mediated activation
of a SRC family kinase is not required to initiate Ca2+ release at
fertilization in mouse eggs. Reproduction: 129: 557-564.
Freudzon, L., Norris, R.P., Hand, A.R., Tanaka, S., Saeki, Y., Jones,
T.L.Z., Rasenick, M.M., Berlot, C.H., Mehlmann, L.M., and Jaffe, L.A.
2005. Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a
constitutive activator of the Gs G protein. J. Cell Biol. 171:255-265.
Mehlmann, L.M., Y. Saeki, S. Tanaka, T.J. Brennan, A.V. Evsikov, F.L.
Pendola, B.B. Knowles, J.J. Eppig, and L.A. Jaffe. (2004). The Gs-linked
receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science
306:1947-1950.
Kalinowski, R.R., Berlot, C.H., Jones, T.L.Z., Ross, L.F., Jaffe,
L.A., and Mehlmann, L.M. (2004). Maintenance of meiotic prophase arrest
in vertebrate oocytes by a Gs protein-mediated pathway. Develop. Biol.
267: 1-13.
Runft, L.L., Jaffe, L.A., and Mehlmann, L.M. (2002). Egg activation
at fertilization: where it all begins. Develop. Biol. 245: 237-254.
Mehlmann, L.M., Jones, T.L.Z., and Jaffe, L.A. (2002). Meiotic arrest
in the mouse follicle maintained by a Gs protein in the oocyte. Science
297: 1343-1345. |
