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Faculty Stefan Brocke
Assistant Professor of Immunology
- M.D., Ph.D., Free University of Berlin, Germany
- Not accepting students for Lab Rotations at this time
Areas of Interest:
My laboratory studies the cellular and molecular mechanisms of brain
injury in inflammatory and inflammation-associated disorders of the
central nervous system. For this purpose, we focus on (1) vascular
triggers leading to the invasion of pathogenic lymphocytes into the
normal and inflamed brain, (2) regulation of inflammatory and
anti-inflammatory processes at the level of cell surface molecules, and
(3) cellular mechanisms regulating injury or survival/regeneration of
neurons in areas affected by inflammation.
Lab Rotation Projects:
Expression and function of lymphocyte recruitment signals at the
blood-CNS barrier.
Selected Publications:
Franitza S, Grabovsky V, Wald O, Weiss I, Beider K, Dagan M,
Darash-Yahana M, Nagler A, Brocke S, Galun E, Alon R, Peled A. 2004.
Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and
CD56+CD16+ NK cells regulates their interaction with endothelial cells.
Eur J Immunol. May;34(5):1333-41.
Beider K, Nagler A, Wald O, Franitza S, Dagan-Berger M, Wald H,
Giladi H, Brocke S, Hanna J, Mandelboim O, Darash-Yahana M, Galun E,
Peled A. 2003. Involvement of CXCR4 and IL-2 in the homing and retention
of human NK and NK T-cells to the bone marrow and spleen of NOD/SCID
mice. Blood. Sep 15;102(6):1951-8.
Aktas O, Waiczies S, Smorodchenko A, Dorr J, Seeger B, Prozorovski T,
Sallach S, Endres M, Brocke S, Nitsch R, Zipp F. 2003. Treatment of
relapsing paralysis in experimental encephalomyelitis by targeting Th1
cells through atorvastatin. J Exp Med. Mar 17;197(6):725-33.
Reinhold D, Kahne T, Steinbrecher A, Wrenger S, Neubert K, Ansorge S,
Brocke S. 2002. The role of dipeptidyl peptidase IV (DP IV) enzymatic
activity in T cell activation and autoimmunity. Biol Chem.
Jul-Aug;383(7-8):1133-8. Review.
Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N, Izikson L,
Born I, Faust J, Neubert K, Martin R, Ansorge S, Brocke S. 2001.
Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune
encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo. J
Immunol. Feb 1;166(3):2041-8.
Brocke S. 2000. T cell receptor peptides for the vaccination therapy
of multiple sclerosis. Ernst Schering Res Found Workshop; (30):167-79.
Review.
Reinhold D, Hemmer B, Gran B, Steinbrecher A, Brocke S, Kahne T,
Wrenger S, Born I, Faust J, Neubert K, Martin R, Ansorge S. 2000.
Dipeptidyl peptidase IV (CD26): role in T cell activation and autoimmune
disease. Adv Exp Med Biol.;477:155-60.
Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N, Izikson L,
Born I, Faust J, Neubert K, Martin R, Ansorge S, Brocke S. 2000.
Dipeptidyl peptidase IV in inflammatory CNS disease. Adv Exp Med
Biol.;477:145-53. |
