Ph.D. in Biomedical Science: Area of Concentration
Skeletal, Craniofacial & Oral Biology
Faculty
Andrew Arnold,
Professor of Medicine and Murray-Heilig Chair in Molecular Medicine,
M.D., Harvard University. The molecular genetic underpinnings of tumors
of the endocrine glands. Role of cyclin D1 in tumorigenesis.
Felix Bronner,
Professor Emeritus of Oral Rehabilitation, Biomaterials and Skeletal
Development, Center for Regenerative Medicine and Skeletal Development, Ph.D. Mass. Inst.
Tech., Cambridge. 1) Calcium Homeostasis, 2) Calcium Transport in
Intestine and Kidney, 3) Calcium in Bones and Teeth, 4) Ion Transport,
5) Metabolic Bone Diseases.
Caroline N.
Dealy, Associate Professor of Oral Rehabilitation, Biomaterials and
Skeletal Development, Center for Regenerative Medicine and Skeletal
Development. Ph.D. University of Connecticut. Molecular regulation of
vertebrate limb development, limb patterning, cartilage and bone
differentiation, growth factor signaling, joint development, human
embryonic stem cell differentiation.
Anne Delany, Assistant
Professor of Medicine. Ph.D. Dartmouth Medical School. Study of
non-collagen matrix proteins in normal bone remodeling and the impact of
microenvironment on tumor development and metastasis.
Anna
Dongari-Bagtzoglou, Assistant Professor, Department of Oral Health
and Diagnostic Sciences, Division of Periodentology, D.D.S.
Aristotle University, Greece, M.S. University of California, Los
Angeles, Ph.D. University of Texas, San Antonio. Pathogenesis of oral
opportunistic infections in the immunocompromised host. Regulation of
oral mucosal inflammation in response to bacterial or fungal infection.
Innate immune factors which limit oral mucosal infection and invasion.
Paul M.
Epstein, Associate Professor of Pharmacology, Ph.D. Albert Einstein
College of Medicine. Second messengers and signal transduction.
Particular focus on cyclic nucleotide metabolism and protein
phosphorylation, with emphasis on analysis of cyclic nucleotide
phosphodiesterase (PDE).
Marion Frank,
Professor of Oral Health and Diagnostic Sciences; Director, Center for
Neurosciences, Ph.D. Brown University. Study of the sense
of taste using basic and clinical research. Development of a fundamental
understanding of gustatory systems in mammals, at all levels from
receptors to cerebral cortex. Application of basic knowledge of
gustatory systems to the diagnosis and treatment of taste disorders in
humans.
A. Jon
Goldberg, Professor of Oral Rehabilitation, Biomaterials and Skeletal
Development, Center for Regenerative Medicine and Skeletal Development, Ph.D. University of Michigan. Biomaterials, with
studies involving structure-property relationships, development of novel
systems, clinical evaluations and surface analysis.
Gloria
Gronowicz, Professor and Director of Orthopaedic Research,
Department of Orthopaedics, Ph.D. Columbia University. Effects of
hormones and growth factors on the production of extracellular matrix (ECM)
proteins, on the regulation of integrins (receptors for ECM proteins)
and on apoptosis in bone; response of bone cells to implant
biomaterials.
Arthur R. Hand,
Professor of Orthodontics and Maxillofacial Surgery, Pediatric Dentistry
and Advanced Education in General Dentistry, Division of Pediatric
Dentistry, D.D.S. University of California, Los
Angeles. Study of gene expression in rodent salivary glands during
normal growth and development and in various experimental conditions
employing morphological, immunological and biochemical methodology.
Marc Hansen,
Professor of Medicine, M.S. University of Wisconsin, Ph.D. University
of Cincinnati College of Medicine. Molecular genetics of osteosarcoma
and related bone diseases.
Marja Hurley,
Professor of Medicine, M.D., University of Connecticut School of
Medicine. Molecular
mechanisms by which members of the fibroblast growth factor (FGFs) and
fibroblast growth factor receptor (FGFR) families, (produced by
osteoblasts, osteoclasts and stromal cells) regulate bone development,
remodeling and disorders of bone. Fgf2 knockout and Fgf2 transgenic mice
are utilized in loss and gain of function experiments to elucidate the
role of FGF-2 in disorders of bone including osteoporosis.
Robert A.
Kosher, Professor of Oral Rehabilitation, Biomaterials and Skeletal
Development, Center for Regenerative Medicine and Skeletal Development, Ph.D. Temple
University. Limb development; roles and relationships among regulatory
genes particularly homeobox-containing genes, secreted signaling
molecules, and the extracellular matrix in the regulation of limb
formation, outgrowth, patterning, cartilage differentiation,
osteogenesis, and joint formation.
Barbara Kream,
Professor of Medicine and Genetics and Developmental Biology. Ph.D.,
Yale University. Hormonal regulation of bone remodeling.
Liisa T. Kuhn,
Assistant Professor of Oral Rehabilitation, Biomaterials and Skeletal
Development, Center for Regenerative Medicine and Skeletal Development. Ph.D. University of
California-Santa Barbara. Biomaterials for drug delivery and bone
regeneration and repair.
Marc Lalande,
Professor and Head, Dept. of Genetics and Developmental Biology. Ph.D.,
University of Toronto. Genomic imprinting of human chromosome 15q.
Leo
Lefrancois, Professor of Medicine and Pathology, B.S., Colorado
State University; Ph.D., Wake Forest University. T lymphocyte
development, mucosal immunology, intestinal intraepithelial T
lymphocytes, gamma/delta T cells.
Alexander
Lichtler, Associate Professor of Genetics and Developmental Biology,
Ph.D., University of Florida, Gainsville. Hormone regulation of bone
collagen synthesis.
Alan G. Lurie,
Professor of Oral Health and Diagnostic Sciences; Head, Division of Oral and Maxillofacial Radiology, D.D.S., UCLA,
Ph.D., Univ. of Rochester. Digital imaging analysis of dental and bone
diseases .
Sanjay Mallya,
Assistant Professor of Oral Health and Diagnostic Sciences, Division of
Oral Diagnosis, B.D.S, M.D.S., University of
Bombay; Ph.D., University of Connecticut. Molecular genetics of oral
cancer, Effects of parathyroid hormone on bone.
Mina Mina,
Professor of Orthodontics and Maxillofacial Surgery, Pediatric Dentistry
and Advanced Education in General Dentistry; Head, Division of Pediatric
Dentistry, D.M.D., National University of Iran,
Ph.D., University of Connecticut Health Center. Development of the
mandibular arch including the elongation and polarized outgrowth of the
mandibular primordia and subsequent differentiation of the skeletal
tissues in spatially defined patterns. Characterization of genetic and
epigenetic influences involved in the pattern formation and
skeletogenesis of the chick mandible and mouse tooth germ. Regulation of
patterning in the developing mandible and developing teeth by mandibular
epithelium, extracellular matrix molecules, growth factors, and
transcription factors.
Carol C.
Pilbeam, Professor of Medicine; PhD., University of Yale, 1982.
M.D., Yale School of Medicine. Mechanisms of regulation of bone
formation and resorption.
Justin Radolf,
Professor of Medicine and Center for Microbial Pathogenesis, M.D.,
University of California, San Francisco. Molecular pathogenesis and
immunobiology of spirochetal infections.
Ernst
Reichenberger, Assistant Professor of Oral Rehabilitation,
Biomaterials and Skeletal Development, Center for Regenerative Medicine
and Skeletal Development.
Ph.D., University of Erlangen. The Reichenberger laboratory is
interested in learning about the complex processes required for
generating and maintaining the skin and bones. To find out how the
mechanisms operate in a healthy person, we study human genetic disorders
in which they are disrupted.
Blanka Rogina,
Assistant Professor of Genetics and Developmental Biology, Ph.D., Zagreb
University School of Medicine. Biology of aging including the molecular
genetic determinants of aging and longevity.
Edward F.
Rossomando, Professor of BioStructure and Function, D.D.S.,
University of Pennsylvania, Ph.D., Rockefeller University, M.S.
(Management) Rensselaer Polytechnic Institute. Translational research,
strategic management, entrepreneurship, management of innovation and
technology, strategic management in the healthcare industry.
David W. Rowe,
Professor of Genetics and Developmental Biology, M.D. University of
Vermont. Genetic and hormonal control of type I collagen production.
Development of strategies for somatic gene therapy for heritable
diseases of bone built upon the structural and regulatory principles of
collagen production.
Jason M.
Tanzer, Professor and Division Head, Oral Medicine, Department of
Oral Diagnosis, School of Dental Medicine; also, Professor of Clinical
Microbiology, Department of Laboratory Medicine, School of Medicine.
D.M.D. Tufts University School of Dental Medicine; Ph.D. Georgetown
University; D.H.C. Sahlgrenska Academy at the University of Gothenburg,
Sweden. 1. The physiological/biochemical/genetic bases of virulence by
the mutans streptococci (Streptococcus mutans) and its
colonization of the teeth and the physiological/biochemical/genetic
bases of non-virulence of Streptococcus gordonii despite its avid
colonization of the teeth. 2. The colonization determinants of certain
HIV-inhibiting Lactobacillus species in the
oral-gastro-intestinal tract.
William B.
Upholt, Professor of Oral Rehabilitation, Biomaterials and Skeletal
Development, Center for Regenerative Medicine and Skeletal Development;
Director, Skeletal, Craniofacial and Oral Biology Graduate Program, Ph.D., California
Institute of Technology. Molecular mechanisms regulating differentiation
and pattern formation during embryonic skeletal development in the limb
and mandible. Use of transgenic mouse model systems. Study of the
regulation of the process of chondrogenesis. |
