Research Interest
The primary interest of our research is the investigation of
the basic biology of aging, including the molecular genetic
determinants of aging and longevity. Over the past few years our
work has concentrated on understanding some of the mechanisms
that regulate gene expression during adult life in Drosophila
melanogaster. Currently we are involved in screening for
genes that are involved in life span determination. Another
interest is to investigate the biological deterinants of female
longevity. Female life spans dependents on reproductive status.
It is our goal to study the contribution reproduction and
fertility make toward female longevity.
Selected Publications
Parashar, V. and Rogina B. 2010. dSir2 and fly mobility. Cell
Cycle. 2010 Feb;9(3):433.
Rogina, B. 2009. The effect of sex peptide and calorie intake
on fecundity in female Drosophila melanogaster.
ScientificWorldJournal. 9: 1178-89.
Parashar, V. and Rogina, B. 2009. dSir2 mediates the
increased spontaneous physical activity of flies on calorie
restriction, Aging, 1: 529-541.
http://www.impactaging.com/advance.html
Wang, P.Y., Neretti, N.,Whitaker, R., Hosier, S., Chang, C.
Lu, D., Rogina, B., Helfand, S.L. 2009. Long-lived Indy and
calorie restriction interact to extend life span. Proc. Natl.
Acad. Sci. U S A. 106: 9262-7 Selected for Cellıs Leading Edge,
Cell Biology section, July10th issue of Cell
Neretti, N., Wang, P.Y., Brodsky, A.S., Nyguyen, H.H., White,
K.P., Rogina, B#., Helfand SL.# 2009. Long-lived Indy induces
reduced mitochondrial reactive oxygen species production and
oxidative damage. Proc. Natl. Acad.Sci. U S A.106: 2277-82
#co-corresponding authors
Parashar, V., Frankel, S., Lurie, A.G. and Rogina, B. 2008.
The effects of age on radiation resistance and oxidative stress
in adult Drosophila melanogaster. Radiat Res.169:707-11.
Reenan, R.A. and Rogina, B#. 2008. Acquired
temperature-sensitive paralysis as a biomarker of declining
neuronal function in aging Drosophila. Aging Cell 7: 179-86
Rogina, B#., Wolverton, T., Bross, T.G., Chen, K., Müller,
H-G., and Carey, J.R. 2007. Distinct Biological Epochs in the
reproductive life of Drosophila melanogaster. Mech. Ageing Dev.
128: 477-485 #corresponding author
Knauf, F., Mohebbi, N., Teichert, C., Herold, D., Rogina, B.,
Helfand, S., Gollasch, M., Luft, F.C. and P.S. Aronson. 2006.
The life-extending gene Indy encodes an exchanger for
Krebs-cycle intermediates. Biochem J. 397: 25-9.
Frankel, S., and Rogina, B#. 2006. Sir2, caloric restriction
and aging, Pathol. Biol. (Paris) 54: 55-7 #corresponding author
Bross, T.G., Rogina, B. and Helfand, S.L. 2005. Behavioral,
physical, and demographic changes in Drosophila populations
through dietary restriction. Aging Cell 4: 309-317
Frankel S., and Rogina, B. 2005. Drosophila longevity is not
affected by heterochromatin-mediated gene silencing. Aging Cell
4: 53-56.
Rogina, B. and Helfand, S.L. 2004. Sir2 mediates longevity in
the fly through a pathway related to calorie restriction. Proc.
Natl. Acad. Sci. USA. 101:15998-6003.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15520384
Woods*, J.G., Rogina*, B., Lavu, S., Howitz, K., Helfand, S.L.,
Tatar, M. and Sinclair, D. 2004. Sirtuin activators mimic
caloric restriction and delay ageing in metazoans. Nature
430:686-689. *These authors contributed equally to the work.
Marden, J.H *., Rogina, B*. Montooth, K.L. and Helfand S.L.
2003. Conditional tradeoffs between aging and organismal
performance of Indy long-lived mutant flies. Proc. Natl. Acad.
Sci. USA, 100: 3369-3373. (*Theses authors contributed equally
to this work.)
Helfand S. L. and Rogina, B. 2003. Molecular Genetics of
Aging in the Fly: Is this the End of the Beginning? BioEssays,
25: 134-141.
Rogina, B. , Helfand, S.L. and Frankel S. 2002."Longevity
regulation by Drosophila Rpd3 deacetylase and caloric
restriction." Science, 298: 1745.
Knauf, F *., Rogina, B *., Jiang, Z., Aronson, P. and Helfand,
S.L. 2002. Functional Characterization and Immunolocalization of
the Novel Transporter Encoded by the Life-Extending Gene Indy.
Proc. Natl. Acad. Sci. USA, 99: 14315-14319, 2002. (*These
authors contributed equally to this work.)
Blanka Rogina , Robert A. Reenan, Steven P. Nilsen, and
Stephen L. Helfand. 2000. Extended Life-Span Conferred by
Cotransporter Gene Mutations in Drosophila. Science,290:
2137-2140.
Rogina, B. and Helfand, S.L. 2000. Cu, Zn superoxide
dismutase deficiency accelerates the time course of an
age-related marker in Drosophila melanogaster. Biogerontology,
1: 163-169.
Book chapters:
Helfand, S.L. and Rogina, B. 2003. From Genes to Aging in
Drosophila, in "Genetics of Aging", ed.: Hall, J.C., Dunlap and
J.C., Friedmann, F. Advances in Genetics, Academic Press, San
Diego 49: 67-109.
Helfand, S.L. and Rogina, B. 2000. Regulation of Gene
Expression During Aging, in Results and Problems in Cell
Differentiation. ed. Hekimi S.: The Molecular Genetics of Aging,
Springer-Verlag, Berlin Heidelberg, Germany, 29.
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