Areas of Interest
One of the major interests of my laboratory has been to
elucidate the mechanisms regulating mandibular outgrowth and
morphogenesis with an emphasis on the roles of signaling factors
secreted by mandibular epithelium. Currently we are focusing on
the specific and interactive roles of two signaling pathways
regulated by FGFs and BMPs in the morphogenesis of the
developing mandible.
Second area of interest of my laboratory is signaling
pathways regulating the initial stages of tooth formation.
Currently we are focusing on the possibility of engineering
tooth crowns. Towards this goal, experiments are in progress to
examine the multiple differentiation potentials of dental pulp.
Lab Rotation Projects
Students with new and innovative ideas about craniofacial and
tooth development are more than welcome to participate in
rotation project in the laboratory. In addition the students can
participate in the ongoing projects in the lab.
The current research projects in the laboratory are:
1. Understanding the mechanisms regulating proper outgrowth
and morphogenesis of mandibular processes.
2. Understanding the differentiation potentials of dental
pulp and its application towards tissue engineering.
Selected Publications
Savage T, Bennett T, Huang YF, Kelly PL, Durant NE, Adams DJ,
Mina M, Harrison JR. (2006) Mandibular phenotype of p20C/EBPbeta
transgenic mice: Reduced alveolar bone mass and site-specific
dentin dysplasia.
Bone. 2006 May 5; [Epub
ahead of print]
Havens BA, Rodgers B, Mina M. (2006) Tissue-specific
expression of Fgfr2b and Fgfr2c isoforms, Fgf10 and Fgf9 in the
developing chick mandible. Arch Oral Biol. 51(2):134-45.
Balic A, Mina M. (2005) Analysis of developmental potentials
of dental pulp in vitro using GFP transgenes. Orthod
Craniofac Res. 8(4):252-8.
Bilic-Curcic I, Kronenberg M, Jiang X, Bellizzi J, Mina M,
Marijanovic I, Gardiner EM, Rowe DW. (2005) Visualizing levels
of osteoblast differentiation by a two-color promoter-GFP
strategy: Type I collagen-GFPcyan and osteocalcin-GFPtpz.
Genesis. 43(2):87-98.
Jiang X, Kalajzic Z, Maye P, Braut A, Bellizzi J, Mina M,
Rowe DW. (2005)
Histological analysis of GFP expression in murine bone. J
Histochem Cytochem. 53(5):593-602.
Liu F, Woitge HW, Braut A, Kronenberg MS, Lichtler AC, Mina
M, Kream BE. (2004) Expression and activity of osteoblast-targeted
Cre recombinase transgenes in murine skeletal tissues. Int J
Dev Biol. 48(7):645-53.
Mina M, Braut A. (2004) New insight into progenitor/stem
cells in dental pulp using Col1a1-GFP transgenes. Cells
Tissues Organs. 176(1-3):120-33.
Braut A, Kollar EJ, Mina M. (2003) Analysis of the
odontogenic and osteogenic potentials of dental pulp in vivo
using a Col1a1-2.3-GFP transgene. Int J Dev Biol.
47(4):281-92.
Kalajzic Z, Liu P, Kalajzic I, Du Z, Braut A, Mina M, Canalis.
E, and Rowe D.W. (2002) directing the Expression of GFP
transgene in Differentiated osteoblasts: A comparison between
Rat type I Collagen and Rat Osteocalcin promoters. Bone:
31: 654-660.
Braut A, Kalajzic I, Kalajzic Z, Rowe DW, Kollar ED, and Mina
M (2002) Col1a1-GFP transgene expression in developing incisors.
Conn Tissue Res. 43: 216-219.
Tadic T, Dodig M, Erceg I, Marijanovic I, Mina M, Kalajzic Z,
Velonis D, Kronenberg MS, Kosher RA, Ferrari D, and Lichtler AC
(2002). Overexpression of Dlx5 in chicken calvaria cells
accelerates osteoblastic differentiation. J Bone Miner Res
17: 1008-14.
Mina M, Wang, Y-H, Ivanisevic A-M, and Rodgers B (2002)
Region- and Stage-Specific Effects of FGFs and BMPs in Chick
Mandibular Morphogenesis. Dev. Dyn. 223:333-352
Mina M. (2001). Regulation of mandibular growth and
morphogenesis. J. Craniofac. Genet. Dev. Biol.
12:276-300.
Mina, M. (2001). Morphogenesis of the medial region of the
developing mandible is regulated by multiple signaling pathways.
Cells Tissues Organs, 169: 295-301.
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