Areas of Interest
Use of receptor-mediated endocytosis as a natural mechanism for
targeting substances to specific cell-types.
- Targeted gene delivery for correction of genetic
metabolic disorders.
- Development of antisense and ribozyme strategies for
treatment of viral diseases.
- Modification of viruses to alter infection specificity.
Selected Publications
Wu, C.H., Sapozhnikov, E., and Wu, G.Y.: Evaluation of
multicomponent non-viral vectors for liver directed gene
delivery. J. Drug Target. 10(2), 105-111, (2002).
Smith, R.M., and Wu, G.Y.: Secondary structure and
hybridization accessibility of hepatitis C virus 3'-terminal
sequences. J. Virol. 76:9563-9574 (2002).
Wu, C.H., Ouyang, E.C., Walton, C.M. and Wu, G.Y. Human
hepatocytes transplanted into genetically immunocompetent rats
are susceptible to infection by hepatitis B virus in situ. J.
Viral Hepatitis 8:111-119 (2001).
Ouyang, E.C., Wu, C.H., Walton, C.M., Promrat, K., and Wu,
G.Y.: Transplantation of human hepatocytes into tolerized
genetically immunocompetent rats. Wld. J. Gastro. 7:324-330
(2001).
Wu, G.Y. Walton, CM, and Wu, CH: Targeted polynucleotides for
inhibition of hepatitis B and C viruses. Croat. Med J.
42:463-466 (2001).
Wu, C.H., Ouyang, E.C., Walton, C.M and Wu, G.Y.: Liver cell
transplantation. Novel model for human hepatic viral infections.
Croat. Med J. 42: 446-450 (2001).
Walton, C.M., Wu, C.H., and Wu, G.Y.: A ribonuclease H-oligo
DNA conjugate that specifically cleaves hepatitis B viral
messenger RNA. Bioconj. Chem. 12:770-775 (2001).
Fukuma, T. Wu, G.Y., and Wu, C.H.: Liver-selective nucleic
acid targeting using the asialoglycoprotein receptor. Gene Ther
Reg 1:79-94 (2000).
Wu, C.H and Wu, G.Y.: Gene therapy applications in
gastroenterology and hepatology. Can J. Gastroenterology
14:57-61 (2000).
Promrat, K., Wu, G.Y. and Wu, C.H.: Gene therapy for
metabolic diseases of the liver. BioDrugs 13:177-188 (2000).
Wu, C.H., Walton, C.M. and Wu, G.Y.: Targeted inhibition of
type I procollagen synthesis by antisense DNA oligonucleotides.
Gene Ther. and Reg. 1:193-205 (2000).
Wu, G.Y. Gene therapy: The state of the art. Gastroenterol.
Today 4:183-186 (2000).
Smith, R.M. and Wu, G.Y.: Gene therapy for viral hepatitis:
Prospects for the design and delivery of nucleic acid
pharmaceuticals. Viral Hep. Rev. 6:129-141 (2000).
Fukuma, T., Wu, G.Y. and Wu, C.H.: Liver-selective nucleic
acid targeting using the asialoglycoprotein receptor. Gene Ther
Reg 1:66-79(2000). |
