Areas of Interest
The major focus of this laboratory centers on the immunology
and pathogenesis of viral infections. The majority of our work
has utilized murine cytomegalovirus (MCMV), although studies
have also involved rat CMV, human CMV. At present we are focused
on two areas: vaccine modification of host immunity to CMV and
the initial host defenses in viral re-exposure. For the vaccine
studies, we have constructed vaccines expressing specific MCMV
genes, using vaccinia virus and a replication-deficient
adenovirus as vectors. The studies of host responses to virus
rechallenge have examined the innate and adaptive immune
responses of the host upon re-infection at a mucosal surface.
Selected Publications
Shanley, J. D., Wu, C.A. Mucosal Immunzation with a
Replication-Deficient Adenovirus Vector Expressing Murine
Cytomegalovirus glycoprotein B Induces Mucosal and Systemic
Immunity. Vaccine 21:2632-2642, 2003.
Shanley, J. D., Shanley, J. A. Albert, G., Biegel D.
Characterization of Virus Induced IFN-g Responses in Mice
Previously Infected With Murine Cytomegalovirus, J. Infect Dis.
183: 697-706, 2001.
Loh, L., Keeler, V.D., Shanley, J.D. Sequence Requirements
for the nuclear localization of the murine cytomegalovirus M44
gene product pp50. Virology 259, 43-59, 1999.
Wu CA, Carlson, ME, Henry, SC, Shanley J.D. The murine
cytomegalovirus M25 open reading frame encodes a component of
the tegument. Virology. 262, 265-76, 1999.
Andjelkovic. A.V., Kerkovich, D., Shanley, J.D., Pulliam, L.
and Pachter, J.S. 1999. Expression of binding sites for b
chemokines on human astrocytes. GLIA 28:225-235, 1999. |
