Research Interest
The primary interest of our research is the investigation of
the basic biology of aging, including the molecular genetic
determinants of aging and longevity. Over the past few years our
work has concentrated on understanding some of the mechanisms
that regulate gene expression during adult life in Drosophila
melanogaster. Currently we are involved in screening for
genes that are involved in life span determination. Another
interest is to investigate the biological deterinants of female
longevity. Female life spans dependents on reproductive status.
It is our goal to study the contribution reproduction and
fertility make toward female longevity.
Selected Publications
Helfand, S.L. and Rogina, B.: Molecular Genetics of Aging in
the Fly: Is this the End of the Beginning? BioEssays, 25:
1-8, 2003.
Rogina, B., Helfand, S.L. and Frankel S.: "Longevity
regulation by Drosophila Rpd3 deacetylase and caloric
restriction", Science, 298:1745, 2002.
Knauf, F*., Rogina, B*., Jiang, Z., Aronson, P. and Helfand,
S.L.: Functional Characterization and Immunolocalization of the
Novel Transporter Encoded by the Life-Extending Gene Indy,
Proc. Natl. Acad. Sci. USA, 99: 14315-14319, 2002. *Theses
authors contributed equally to this work.
Rogina, B., Reenan, R.A., Nilsen, S.P. and Helfand, S.L.:
Extended Life-span Conferred by Cotransporter Gene Mutations in
Drosophila, Science, 290: 2137-2140 2000.
Rogina, B. and Helfand, S.L.: Cu, Zn superoxide dismutase
deficiency accelerates the time course of an age-related marker
in Drosophila melanogaster, Biogerontology, 1:
163-169 2000.
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