Areas of Interest
Physiology and anatomy of the mammalian auditory system. A
primary focus of our research is to understand the neural basis
of binaural hearing, with a special emphasis on the processing
of interaural time disparities (ITDs). ITD is a major cue for
localizing sounds along the azimuth. To accomplish this goal, we
have studied binaural processing at each major level along the
ascending auditory pathway, including the superior olivary
complex, dorsal nucleus of the lateral lemniscus, inferior
colliculus, auditory thalamus, and auditory cortex. Since we
have shown that anesthesia alters the response properties of
binaural neurons, all of our studies have been conducted using
an unanesthetized rabbit preparation. Our primary technique is
to extracellularly record the responses of neurons to monaural
and binaural sounds, but we have also employed intracellular
recording and staining techniques to examine the synaptic inputs
and morphology of binaural neurons. Another research interest is
in the development of a non-invasive electro-audiometric
technique to assess hearing disorders in newborns and children.
Publications
Selected Publications
D'Angelo WR, Sterbing SJ, Ostapoff EM, Kuwada S. (2003) Effects
of amplitude modulation on the coding of interaural time
differences of low-frequency sounds in the inferior colliculus.
II. Neural mechanisms.J Neurophysiol. Nov;90(5):2827-36.
Sterbing SJ, D'Angelo WR, Ostapoff EM, Kuwada S. (2003)
Effects of amplitude modulation on the coding of interaural time
differences of low-frequency sounds in the inferior colliculus.
I. response properties. J Neurophysiol. Nov;90(5):2818-26.
Fitzpatrick DC, Kuwada S, Batra R. (2002) Transformations in
processing interaural time differences between the superior
olivary complex and inferior colliculus: beyond the Jeffress
model. Hear Res. Jun;168(1-2):79-89.
Kuwada S, Anderson JS, Batra R, Fitzpatrick DC, Teissier N,
D'Angelo WR. (2002) Sources of the scalp-recorded
amplitude-modulation following response. J Am Acad Audiol.
Apr;13(4):188-204.
Fitzpatrick DC, Kuwada S. (2001) Tuning to interaural time
differences across frequency. J Neurosci. Jul 1;21(13):4844-51.
Fitzpatrick DC, Kuwada S, Batra R. (2000) Neural sensitivity
to interaural time differences: beyond the Jeffress model. J
Neurosci. Feb 15;20(4):1605-15.
 View more publications, see
Pubmed listing. |
