Areas of Interest
My research concerns the cell biology of fertilization, and the
regulation of meiosis in oocytes. Questions of interest include
how the sperm activates the egg to begin development, and how
the oocyte matures to become a fertilization-competent egg.
Currently we are investigating the role of a G-protein-linked
receptor, GPR3, in the maintenance of meiotic prophase arrest in
follicle-enclosed mouse oocytes.
Selected Publications
Mehlmann, L.M., and Jaffe, L.A. 2005. SH2 domain-mediated
activation of a SRC family kinase is not required to initiate
Ca2+ release at fertilization in mouse eggs. Reproduction: 129:
557-564.
Freudzon, L., Norris, R.P., Hand, A.R., Tanaka, S., Saeki,
Y., Jones, T.L.Z., Rasenick, M.M., Berlot, C.H., Mehlmann, L.M.,
and Jaffe, L.A. 2005. Regulation of meiotic prophase arrest in
mouse oocytes by GPR3, a constitutive activator of the Gs G
protein. J. Cell Biol. 171:255-265.
Mehlmann, L.M., Y. Saeki, S. Tanaka, T.J. Brennan, A.V.
Evsikov, F.L. Pendola, B.B. Knowles, J.J. Eppig, and L.A. Jaffe.
(2004). The Gs-linked receptor GPR3 maintains meiotic arrest in
mammalian oocytes. Science 306:1947-1950.
Kalinowski, R.R., Berlot, C.H., Jones, T.L.Z., Ross, L.F.,
Jaffe, L.A., and Mehlmann, L.M. (2004). Maintenance of meiotic
prophase arrest in vertebrate oocytes by a Gs protein-mediated
pathway. Develop. Biol. 267: 1-13.
Runft, L.L., Jaffe, L.A., and Mehlmann, L.M. (2002). Egg
activation at fertilization: where it all begins. Develop. Biol.
245: 237-254.
Mehlmann, L.M., Jones, T.L.Z., and Jaffe, L.A. (2002).
Meiotic arrest in the mouse follicle maintained by a Gs protein
in the oocyte. Science 297: 1343-1345. |
