Areas of Interest
My laboratory studies the cellular and molecular mechanisms of
brain injury in inflammatory and inflammation-associated
disorders of the central nervous system. For this purpose, we
focus on (1) vascular triggers leading to the invasion of
pathogenic lymphocytes into the normal and inflamed brain, (2)
regulation of inflammatory and anti-inflammatory processes at
the level of cell surface molecules, and (3) cellular mechanisms
regulating injury or survival/regeneration of neurons in areas
affected by inflammation.
Lab Rotation Projects
Expression and function of lymphocyte recruitment signals at the
blood-CNS barrier.
Selected Publications
Franitza S, Grabovsky V, Wald O, Weiss I, Beider K, Dagan M,
Darash-Yahana M, Nagler A, Brocke S, Galun E, Alon R, Peled A.
2004. Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT
cells and CD56+CD16+ NK cells regulates their interaction with
endothelial cells. Eur J Immunol. May;34(5):1333-41.
Beider K, Nagler A, Wald O, Franitza S, Dagan-Berger M, Wald
H, Giladi H, Brocke S, Hanna J, Mandelboim O, Darash-Yahana M,
Galun E, Peled A. 2003. Involvement of CXCR4 and IL-2 in the
homing and retention of human NK and NK T-cells to the bone
marrow and spleen of NOD/SCID mice. Blood. Sep 15;102(6):1951-8.
Aktas O, Waiczies S, Smorodchenko A, Dorr J, Seeger B,
Prozorovski T, Sallach S, Endres M, Brocke S, Nitsch R, Zipp F.
2003. Treatment of relapsing paralysis in experimental
encephalomyelitis by targeting Th1 cells through atorvastatin. J
Exp Med. Mar 17;197(6):725-33.
Reinhold D, Kahne T, Steinbrecher A, Wrenger S, Neubert K,
Ansorge S, Brocke S. 2002. The role of dipeptidyl peptidase IV
(DP IV) enzymatic activity in T cell activation and
autoimmunity. Biol Chem. Jul-Aug;383(7-8):1133-8. Review.
Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N,
Izikson L, Born I, Faust J, Neubert K, Martin R, Ansorge S,
Brocke S. 2001. Targeting dipeptidyl peptidase IV (CD26)
suppresses autoimmune encephalomyelitis and up-regulates TGF-beta
1 secretion in vivo. J Immunol. Feb 1;166(3):2041-8.
Brocke S. 2000. T cell receptor peptides for the vaccination
therapy of multiple sclerosis. Ernst Schering Res Found
Workshop; (30):167-79. Review.
Reinhold D, Hemmer B, Gran B, Steinbrecher A, Brocke S, Kahne
T, Wrenger S, Born I, Faust J, Neubert K, Martin R, Ansorge S.
2000. Dipeptidyl peptidase IV (CD26): role in T cell activation
and autoimmune disease. Adv Exp Med Biol.;477:155-60.
Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N,
Izikson L, Born I, Faust J, Neubert K, Martin R, Ansorge S,
Brocke S. 2000. Dipeptidyl peptidase IV in inflammatory CNS
disease. Adv Exp Med Biol.;477:145-53. |
