Areas of Interest
Developmental, cellular and molecular biology of
Oligodendrocytes, the cells that synthesize myelin membrane in
the central nervous system; growth factor regulation of
development and function and its relationship to
neurodegenerative disease, including Multiple Sclerosis.
Current research is focused on investigation of basic
mechanisms of cell biology in a developmental context. (oligodendrocyte
developmental lineage is the model system)
- Molecular mechanisms of regulation of differentiation by
growth factor receptors, including the application of
transgenic mouse models, cell culture and transfection
systems.
- Membrane biogenesis and function, including the role of
glycosphingolipid-cholesterol microdomains (rafts) and
signal transduction.
- The relationship of these to Multiple Sclerosis
Lab Rotation Projects
Contact Dr. Bansal for deatils on available rotation projects.
Selected Publications
Furusho M, Dupree JL, Bryant M, Bansal R. (2009): Disruption of
fibroblast growth factor receptor signaling in nonmyelinating
Schwann cells causes sensory axonal neuropathy and impairment of
thermal pain sensitivity. J Neurosci. 29:1608-14.
Bryant M, Marta CB, Kim FS, Bansal R. (2009): Phosphorylation
and lipid raft association of fibroblast growth factor
receptor-2 in oligodendrocytes. Glia. 2008 Dec 2. [Epub ahead of
print].
Anitei M, Cowan A, Pfeiffer SE, Bansal R (2009): Role for Rab3a
oligodendrocyte morphological differentiation. J. Neurosci. Res.
87:342-52.
Marta CB, Bansal R, Pfeiffer SE (2008): Microglial Fc receptors
mediate physiological changes resulting from antibody
cross-linking of myelin oligodendrocyte glycoprotein (MOG). J.
Neuroimmunology 196:35-40.
Kaga Y, Shoemaker WJ, Furusho M, Bryant M, Rosenbluth J,
Pfeiffer SE, Oh L, Rasband M, Lappe-Siefke C, Yu K, Ornitz DM,
Nave KA, Bansal R (2006): Mice with conditional inactivation of
FGF receptor-2 signaling in oligodendrocytes have normal myelin
but display dramatic hyperactivity when combined with Cnp1
inactivation. J. Neurosci. 26:12339-12350.
Naruse M, Nakahira E, Miyata T, Hitoshi S, Ikenaka K, Bansal R
(2006): Induction of oligodendrocyte progenitors in dorsal
forebrain by intraventricular microinjection of FGF-2. Dev Biol.
297:262-273.
Fortin D, Rom E, Yayon A, Sun H, Bansal R (2005): Distinct FGF/FGF
Receptor signaling pairs initiate diverse cellular responses in
the oligodendrocyte lineage. J Neurosci 25: 7470-7479.
Bansal R, Marin-Husstege M, Bryant M, Casaccia-Bonnefil P
(2005): S-phase entry of oligodendrocyte lineage cells is
associated with increased levels of p21Cip1. J Neurosci Res
80:360-8.
rev. 5/09 |
